Zebrowska Agnieszka, Narbutt Joanna, Sysa-Jedrzejowska Anna, Kobos Jozef, Waszczykowska Elzbieta
Department of Dermatology and Venereology, Medical University of Lodz, Poland.
Mediators Inflamm. 2005 Dec 14;2005(6):373-9. doi: 10.1155/MI.2005.373.
Dermatitis herpetiformis (DH) is a subepidermal autoimmune disease characterized by skin and intestinal lesions consistent with coeliac disease. There are also some data that metalloproteinases (MMPs) are involved in the development of skin lesions in DH, however their exact role in this process is not fully understood. The aim of the study was to investigate whether MMPs and their inhibitors are involved in pathogenesis of DH. Skin biopsies were taken from 13 patients with active DH and from 10 healthy subjects. The localization and expression of MMPs and TIMPs were examined by immunohistochemistry. MMPs expression was detected in basal keratinocytes and in the whole epidermis in all of the DH subjects. Neutrophils in microabscesses and in blister fluid were also positive for MMPs. Expression of TIMPs was moderate or weak in all examined biopsies. Our results allow us to conclude that imbalance between these enzymes takes an important role in the pathogenesis of DH.
疱疹样皮炎（DH）是一种表皮下自身免疫性疾病，其特征为皮肤和肠道病变，与乳糜泻相符。也有一些数据表明金属蛋白酶（MMPs）参与了DH皮肤病变的发展，然而它们在这个过程中的确切作用尚未完全明确。本研究的目的是调查MMPs及其抑制剂是否参与DH的发病机制。从13例活动期DH患者和10名健康受试者身上获取皮肤活检样本。通过免疫组织化学检查MMPs和组织金属蛋白酶抑制剂（TIMPs）的定位和表达。在所有DH受试者中，MMPs在基底角质形成细胞和整个表皮中均有表达。微脓肿和水疱液中的中性粒细胞MMPs也呈阳性。在所有检查的活检样本中，TIMPs的表达为中度或弱阳性。我们的结果使我们得出结论，这些酶之间的失衡在DH的发病机制中起重要作用。
