Lazrek Mouna, Goffard Anne, Schanen Cécile, Karquel Cyrille, Bocket Laurence, Lion Georges, Devaux Marc, Hedouin Valéry, Gosset Didier, Hober Didier
Service de Virologie/UPRES EA 3610, Bâtiment Paul Boulanger, CHRU Université Lille 2, 59037 Lille Cedex, France.
Diagn Microbiol Infect Dis. 2006 May;55(1):55-8. doi: 10.1016/j.diagmicrobio.2005.10.018. Epub 2006 Feb 20.
Forensic medical personnel are at risk of exposure to blood-borne viruses including hepatitis C virus (HCV). The aim of this study was to determine prevalence of HCV markers among a cadaver population at the medicolegal institute in Lille. Seventy-seven consecutive cadavers were screened for antibodies to HCV and for HCV RNA. Positive results were confirmed by an immunoblot assay. Fifty-three cadavers had a histopathologic study. Anti-HCV was detected in 13 (16.9%) and accompanied by HCV RNA in 7 (9%) cases. The rate of HCV RNA detection among seropositive cases was 53.8%. Five cases had histopathologic lesions suggestive of hepatitis. This is the first HCV RNA screening in forensic cadavers. The results highlight the high prevalence rate of HCV cases in medicolegal practice in Lille. All forensic specimens should be treated as potentially infectious and universal precautions should be taken.
法医人员有接触包括丙型肝炎病毒（HCV）在内的血源性病原体的风险。本研究的目的是确定里尔法医机构尸体人群中HCV标志物的流行率。对77具连续的尸体进行了HCV抗体和HCV RNA筛查。阳性结果通过免疫印迹法确认。53具尸体进行了组织病理学研究。13例（16.9%）检测到抗-HCV，其中7例（9%）伴有HCV RNA。血清学阳性病例中HCV RNA的检测率为53.8%。5例有提示肝炎的组织病理学病变。这是首次对法医尸体进行HCV RNA筛查。结果突出了里尔法医实践中HCV病例的高流行率。所有法医标本都应被视为具有潜在传染性，并应采取通用预防措施。
