Bose Rohit, Wrana Jeffrey L
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Cell Biol. 2006 Apr;18(2):206-12. doi: 10.1016/j.ceb.2006.02.005. Epub 2006 Feb 20.
The critical regulator of polarity, Par6, is a key member of a multi-component polarity complex that controls a variety of cellular processes such as asymmetric cell division, establishment of epithelial apico-basal polarity, and polarized cell migration. Recently, we have come to understand how regulation of the Par6 interactome by extracellular cues such as integrin and transforming growth factor beta signalling regulates cell motility and tight junction dissolution. These studies have begun to elucidate how signalling to the polarity complex might regulate pathological processes such as tumour cell invasion and metastasis.
极性的关键调节因子Par6是一个多组分极性复合体的关键成员，该复合体控制多种细胞过程，如不对称细胞分裂、上皮细胞顶-基极性的建立以及极化细胞迁移。最近，我们已经了解到细胞外信号（如整合素和转化生长因子β信号）如何调节Par6相互作用组，进而调控细胞运动性和紧密连接的溶解。这些研究已开始阐明极性复合体的信号传导如何调控肿瘤细胞侵袭和转移等病理过程。
