年龄相关性黄斑变性与视盘杯状凹陷：比弗迪尔姆眼研究
Age-related macular degeneration and optic disk cupping: the Beaver Dam Eye Study.
作者信息
Hall Ellen R, Klein Barbara E K, Knudtson Michael D, Meuer Stacy M, Klein Ronald
机构信息
Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, 610 North Walnut Street, Madison, WI 53726, USA.
出版信息
Am J Ophthalmol. 2006 Mar;141(3):494-7. doi: 10.1016/j.ajo.2005.10.049.
PURPOSE
To examine the association between presence, severity, and extent of lesions of age-related macular degeneration (AMD) and optic disk and cup diameters in a general population.
DESIGN
Cross-sectional study.
METHODS
setting: Population-based. study population: Adults aged 43 to 86 years participating in the Beaver Dam Eye Study. observation procedures: Fundus photographs were graded for lesions of AMD using standard protocols. The photographs were obtained during the baseline examination of the Beaver Dam Eye Study. main outcome measure: Optic disk cupping as related to presence, severity, and extent of lesions of AMD.
RESULTS
There were no significant differences in the vertical optic disk and cup measurements or in the vertical cup to disk ratios by severity of lesions of AMD (P values all greater than .10). In those eyes with late lesions of AMD, there was no association of the size of the lesions or their distribution in the fundus and the extent of cupping.
CONCLUSIONS
From a population perspective, there is no relationship of the presence or severity of AMD and optic disk cupping.
目的
在普通人群中研究年龄相关性黄斑变性（AMD）病变的存在、严重程度及范围与视盘和杯盘直径之间的关联。
设计
横断面研究。
方法
研究背景：基于人群。研究对象：参与比弗迪尔姆眼研究的43至86岁成年人。观察程序：使用标准方案对眼底照片进行AMD病变分级。照片是在比弗迪尔姆眼研究的基线检查期间获取的。主要观察指标：与AMD病变的存在、严重程度及范围相关的视盘杯状凹陷。
结果
AMD病变严重程度在垂直视盘和杯盘测量值或垂直杯盘比方面无显著差异（P值均大于0.10）。在患有晚期AMD病变的眼中，病变大小或其在眼底的分布与杯状凹陷程度之间无关联。
结论
从人群角度来看，AMD的存在或严重程度与视盘杯状凹陷之间没有关系。
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