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The hierarchical approach to the DNA stability problem. I. Patterns in non-equilibrium denaturation and renaturation.解决DNA稳定性问题的分层方法。I. 非平衡变性与复性模式
Biochimie. 1982 Feb;64(2):99-112. doi: 10.1016/s0300-9084(82)80412-4.
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The hierarchical approach to the DNA stability problem. II. Some applications and speculations with yeast mitochondrial DNA as an example.
Biochimie. 1982 Feb;64(2):113-26. doi: 10.1016/s0300-9084(82)80413-6.
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Origin and direction of replication in mitochondrial DNA molecules from the genus Drosophila.果蝇属线粒体DNA分子的复制起点与方向
Nucleic Acids Res. 1980 Feb 25;8(4):741-57.
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Animal mitochondrial DNA: an extreme example of genetic economy.动物线粒体DNA：基因精简的极端例子。
Int Rev Cytol. 1985;93:93-145. doi: 10.1016/s0074-7696(08)61373-x.
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Sequence deduced physical properties in the D-loop region common to five vertebrate mitochondrial DNAs.
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Structural conservation and variation in the D-loop-containing region of vertebrate mitochondrial DNA.脊椎动物线粒体DNA含D环区域的结构保守性与变异性
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Slipped-strand mispairing: a major mechanism for DNA sequence evolution.滑脱链错配：DNA序列进化的主要机制
Mol Biol Evol. 1987 May;4(3):203-21. doi: 10.1093/oxfordjournals.molbev.a040442.
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Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.通过聚合酶链反应生成单链DNA及其在HLA - DQA基因座直接测序中的应用。
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Nucleotide sequence and gene organization of sea urchin mitochondrial DNA.海胆线粒体DNA的核苷酸序列与基因组织
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10
Drosophila mitochondrial DNA: conserved sequences in the A + T-rich region and supporting evidence for a secondary structure model of the small ribosomal RNA.果蝇线粒体DNA：富含A+T区域的保守序列及小核糖体RNA二级结构模型的支持证据
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意大利蜜蜂线粒体DNA中COI和COII之间基因间区域的假定起源与功能。

Putative origin and function of the intergenic region between COI and COII of Apis mellifera L. mitochondrial DNA.

作者信息

Cornuet J M, Garnery L, Solignac M

机构信息

Laboratoire de Neurobiologie Comparée des Invertébrés INRA-CNRS (URA 1190), Bures-sur-Yvette, France.

出版信息

Genetics. 1991 Jun;128(2):393-403. doi: 10.1093/genetics/128.2.393.

DOI:10.1093/genetics/128.2.393
PMID:1649072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1204476/
Abstract

The mitochondrial genome of honeybees is characterized by the presence of a long intergenic sequence located between the COI and COII genes. In addition, the length of this sequence varies between and within subspecies. Four length categories (200, 250, 450 and 650 bp) have been found in 63 sampled colonies. Analysis of the sequence of the largest type reveals the existence of two units: P (54 bp, 100% A + T) and Q (196 bp, 93.4% A + T). The lengths encountered in the sample are explained by the following combinations: Q, PQ, PQQ and PQQQ. According to similarities in primary and secondary structures, the sequence Q has been divided into three parts: Q1 (similar to the 3' end of the COI gene), Q2 (similar to the neighboring tRNA(leu) gene) and Q3 (highly similar to the P sequence). These relationships led us to hypothesize that these sequences, which do not have any counterpart in Drosophila yakuba mitochondrial DNA (mtDNA), arose by tandem duplication. The usual location of length variation in mtDNA control regions prompted us to examine the hypothesis that this COI-COII intergenic region might contain an origin of replication. High A + T content, stability profile, hairpin and cloverleaf putative secondary structures are all in favor of this hypothesis.

摘要

蜜蜂的线粒体基因组的特征是在细胞色素氧化酶亚基I（COI）和细胞色素氧化酶亚基II（COII）基因之间存在一段长的基因间隔序列。此外，该序列的长度在不同亚种之间以及同一亚种内部都有所不同。在63个采样蜂群中发现了四种长度类型（200、250、450和650碱基对）。对最大类型序列的分析揭示了两个单元的存在：P（54碱基对，100%A+T）和Q（196碱基对，93.4%A+T）。样本中出现的长度是由以下组合解释的：Q、PQ、PQQ和PQQQ。根据一级和二级结构的相似性，序列Q被分为三个部分：Q1（类似于COI基因的3'端）、Q2（类似于相邻的亮氨酸转运RNA（tRNA(leu)）基因）和Q3（与P序列高度相似）。这些关系使我们推测，这些在雅库布果蝇线粒体DNA（mtDNA）中没有对应物的序列是通过串联重复产生的。线粒体DNA控制区长度变异的常见位置促使我们检验这一假设，即这个COI-COII基因间隔区可能包含一个复制起点。高A+T含量、稳定性图谱、发夹和三叶草状的假定二级结构都支持这一假设。