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Sequence deduced physical properties in the D-loop region common to five vertebrate mitochondrial DNAs.

作者信息

Mignotte B, Dunon-Bluteau D, Reiss C, Mounolou J C

机构信息

Laboratoire de Biologie Générale, Université de Paris-Sud, Orsay, France.

出版信息

J Theor Biol. 1987 Jan 7;124(1):57-69. doi: 10.1016/s0022-5193(87)80252-7.

DOI:10.1016/s0022-5193(87)80252-7
PMID:3657189
Abstract

Some sequence-induced physical properties of the region of the replication origin in human, mouse, rat, ox and xenopus mitochondrial DNA have been studied: characteristic profiles of stability can be observed, a consensus pattern of hydrogen bond donor/acceptor associated to a symmetrical distribution of base roll angles variation is found upstream of the 5' ends of the D-loop strand. In spite of diversity, evolution has conserved the collective physical properties in parts of the origin of replication region suggesting specific functions for these non-coding sequences.

摘要

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