阿留申水貂病细小病毒的核苷酸序列分析表明，受感染的水貂体内存在多种病毒类型。
Nucleotide sequence analysis of Aleutian mink disease parvovirus shows that multiple virus types are present in infected mink.
作者信息
Gottschalck E, Alexandersen S, Cohn A, Poulsen L A, Bloom M E, Aasted B
机构信息
Department of Veterinary Microbiology, Royal Veterinary and Agricultural University of Copenhagen, Frederiksberg C, Denmark.
出版信息
J Virol. 1991 Aug;65(8):4378-86. doi: 10.1128/JVI.65.8.4378-4386.1991.
Abstract
Different isolates of Aleutian mink disease parvovirus (ADV) were cloned and nucleotide sequenced. Analysis of individual clones from two in vivo-derived isolates of high virulence indicated that more than one type of ADV DNA were present in each of these isolates. Analysis of several clones from two preparations of a cell culture-adapted isolate of low virulence showed the presence of only one type of ADV DNA. We also describe the nucleotide sequence from map units 44 to 88 of a new type of ADV DNA. The new type of ADV DNA is compared with the previously published ADV sequences, to which it shows 95% homology. These findings indicate that ADV, a single-stranded DNA virus, has a considerable degree of variability and that several virus types can be present simultaneously in an infected animal.
摘要
对阿留申水貂病细小病毒（ADV）的不同分离株进行了克隆和核苷酸测序。对来自两个高毒力体内衍生分离株的单个克隆进行分析表明，每个分离株中存在不止一种类型的ADV DNA。对来自低毒力细胞培养适应分离株的两种制剂的几个克隆进行分析，结果显示仅存在一种类型的ADV DNA。我们还描述了一种新型ADV DNA从图谱单位44至88的核苷酸序列。将这种新型ADV DNA与先前发表的ADV序列进行比较，结果显示它们具有95%的同源性。这些发现表明，ADV作为一种单链DNA病毒，具有相当程度的变异性，并且在受感染动物体内可同时存在几种病毒类型。
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