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犬细小病毒:与猫泛白细胞减少症病毒和水貂肠炎病毒野生型及疫苗株的关系

Canine parvovirus: relationship to wild-type and vaccine strains of feline panleukopenia virus and mink enteritis virus.

作者信息

Tratschin J D, McMaster G K, Kronauer G, Siegl G

出版信息

J Gen Virol. 1982 Jul;61 (Pt l):33-41. doi: 10.1099/0022-1317-61-1-33.

DOI:10.1099/0022-1317-61-1-33
PMID:6181186
Abstract

Canine parvovirus (CPV), feline panleukopenia virus (FPLV) and mink enteritis virus (MEV) were compared serologically, by determination of their host range in cell cultures, as well as by restriction enzyme analysis. Maps of the virus genomes were established using seven different restriction enzymes cutting at a total of 56 sites. MEV and FPLV gave maps which were identical except for one restriction site. The map of CPV is closely related to those of FPLV/MEV since their DNAs share about 80% of the restriction sites tested. However, CPV is clearly distinct from FPLV/MEV since either eight (German isolate) or nine (Belgian, Swiss and American isolates) restriction sites are different. The DNAs of six vaccine strains of FPLV and MEV were also analysed. They gave maps which closely resembled those of the respective wild-type strains. CPV and FPLV/MEV also differed with respect to antigenicity, as well as to host range in cell cultures.

摘要

通过血清学方法、在细胞培养物中测定其宿主范围以及限制性内切酶分析,对犬细小病毒(CPV)、猫泛白细胞减少症病毒(FPLV)和水貂肠炎病毒(MEV)进行了比较。使用七种不同的限制性内切酶在总共56个位点进行切割,构建了病毒基因组图谱。MEV和FPLV给出的图谱除一个限制性位点外完全相同。CPV的图谱与FPLV/MEV的图谱密切相关,因为它们的DNA共享约80%的测试限制性位点。然而,CPV明显不同于FPLV/MEV,因为有八个(德国分离株)或九个(比利时、瑞士和美国分离株)限制性位点不同。还分析了FPLV和MEV六种疫苗株的DNA。它们给出的图谱与各自野生型毒株的图谱非常相似。CPV和FPLV/MEV在抗原性以及细胞培养物中的宿主范围方面也存在差异。

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