[The effect of fungi in the pathogenesis of nasal polyps and chronic rhinosinusitis].

OBJECTIVE

To study the effect of fungi in the pathogenesis of nasal polyps and chronic rhinosinusitis (CRS).

METHOD

This study were divided two groups, the first was the experimental group: Nasal mucus membrane and nasal polyps were collected from patients with CRS (with and without polyps), and the second was the control group, nasal mucus were collected from OHc. Fungal-specific PCR were performed on each sample. The anther was used 0.9% sol sodium chloride to wash the autopsy tissues 5 times, and then PCR analysis was performed. chi-squared analysis was used to test for statistical difference between these groups.

RESULT

PCR technique detected fungal DNA were 89.2% and 89.4% in nasal polyps and nasal mucous membrane respectively, and 66.7% in normal control subjective. There were statistically significant difference in these groups. After using 0.9% sol sodium chloride to wash the autopsy tissues, the fungi's positive rate was dropped.

CONCLUSION

Fungi was important in the pathogenesis of nasal polyps and CRS.