Hamze Abdallah, Provot Olivier, Alami Mouâd, Brion Jean-Daniel
Laboratoire de Chimie Thérapeutique, BioCIS - CNRS (UMR 8076), Université Paris-Sud XI, Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
Org Lett. 2006 Mar 2;8(5):931-4. doi: 10.1021/ol052996u.
The first platinum-catalyzed selective silylation of aryl halides including aryl iodides and bromides having an electron-withdrawing group is described. The reaction takes place rapidly in NMP with triethylsilane as a silicon source and sodium acetate to provide functionalized aryltriethylsilanes in moderate to good yields. Heteroaromatic halides also were found to be readily silylated with triethylsilane. The procedure is chemoselective and tolerates a wide variety of functional groups.
首次描述了铂催化的包括带有吸电子基团的芳基碘化物和溴化物在内的芳基卤化物的选择性硅烷化反应。该反应在NMP中以三乙基硅烷为硅源和乙酸钠迅速进行，以中等至良好的产率提供功能化的芳基三乙基硅烷。还发现杂芳基卤化物很容易与三乙基硅烷发生硅烷化反应。该方法具有化学选择性，并且能耐受多种官能团。
