Crich David, Li Wenju
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
Org Lett. 2006 Mar 2;8(5):959-62. doi: 10.1021/ol060030s.
The formation of sialic acid glycosides with a thiosialic acid derivative, diphenyl sulfoxide, and trifluoromethanesulfonic anhydride is reported. With an excess of diphenyl sulfoxide, glycal formation can be completely suppressed and excellent yields are obtained for coupling to a wide range of primary, secondary, and tertiary acceptors.
据报道,硫代唾液酸衍生物、二苯亚砜和三氟甲磺酸酐可形成唾液酸糖苷。在过量二苯亚砜存在下,糖烯的形成可被完全抑制,并且与多种伯、仲和叔受体偶联可获得优异的产率。