Veldhuijzen D S, van Wijck A J M, Wille F, Verster J C, Kenemans J L, Kalkman C J, Olivier B, Volkerts E R
Utrecht Institute for Pharmaceutical Sciences, Rudolf Magnus Institute of Neuroscience, Department of Psychopharmacology, University of Utrecht, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.
Pain. 2006 May;122(1-2):28-35. doi: 10.1016/j.pain.2005.12.019. Epub 2006 Feb 21.
Most pain patients are treated in an outpatient setting and are engaged in daily activities including driving. Since several studies showed that cognitive functioning may be impaired in chronic nonmalignant pain, the question arises whether or not chronic nonmalignant pain affects driving performance. Therefore, the objective of the present study was to determine the effects of chronic nonmalignant pain on actual highway driving performance during normal traffic. Fourteen patients with chronic nonmalignant pain and 14 healthy controls, matched on age, educational level, and driving experience, participated in the study. Participants performed a standardized on-the-road driving test during normal traffic, on a primary highway. The primary parameter of the driving test is the Standard Deviation of Lateral Position (SDLP). In addition, driving-related skills (tracking, divided attention, and memory) were examined in the laboratory. Subjective assessments, such as pain intensity, and subjective driving quality, were rated on visual analogue scales. The results demonstrated that a subset of chronic nonmalignant pain patients had SDLPs that were higher than the matched healthy controls, indicating worse highway driving performance. Overall, there was a statistically significant difference in highway driving performance between the groups. Further, chronic nonmalignant pain patients rated their subjective driving quality to be normal, although their ratings were significantly lower than those of the healthy controls. No significant effects were found on the laboratory tests.
大多数疼痛患者在门诊接受治疗，并参与包括驾驶在内的日常活动。由于多项研究表明慢性非恶性疼痛可能会损害认知功能，因此出现了慢性非恶性疼痛是否会影响驾驶表现的问题。因此，本研究的目的是确定慢性非恶性疼痛对正常交通情况下实际高速公路驾驶表现的影响。14名患有慢性非恶性疼痛的患者和14名年龄、教育水平和驾驶经验相匹配的健康对照者参与了该研究。参与者在正常交通情况下于一条主要高速公路上进行了标准化的道路驾驶测试。驾驶测试的主要参数是横向位置标准差（SDLP）。此外，在实验室中对与驾驶相关的技能（跟踪、分散注意力和记忆）进行了检查。通过视觉模拟量表对疼痛强度和主观驾驶质量等主观评估进行评分。结果表明，一部分慢性非恶性疼痛患者的SDLP高于相匹配的健康对照者，这表明其高速公路驾驶表现较差。总体而言，两组之间在高速公路驾驶表现上存在统计学上的显著差异。此外，慢性非恶性疼痛患者将其主观驾驶质量评为正常，尽管他们的评分明显低于健康对照者。在实验室测试中未发现显著影响。
