Caça I, Unlü K, Büyükbayram H, Ari S
Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakiyr, Turkey.
Eur J Ophthalmol. 2006 Jan-Feb;16(1):168-70. doi: 10.1177/112067210601600128.
Sarcoidosis is an inflammatory disease of unknown cause, characterized by noncaseating granulomas. In this study, the authors present a sarcoidosis patient without systemic signs diagnosed by histopathologic analysis of conjunctival deposits.
A 10-year-old girl had bilateral, focal, multilobular, multiple pale yellow deposits in bulbar conjunctiva for a year. In the patient's biomicroscopic examination, numerous 0.50- to 2-mm diameter pale yellow deposits were determined in both bulbar conjunctivas. The patient had no other systemic or ocular complaints. A conjunctival biopsy was performed.
The biopsy specimens showed noncaseating granulomas with prominent asteroid bodies. Serum angiotensin-converting enzyme levels were increased in the patient. Conjunctival deposits were the first manifestation of sarcoidosis in the patient and the diagnosis of sarcoidosis was confirmed with a conjunctival biopsy.
To the authors' knowledge, this is the second study that reports a sarcoidosis patient with non-systemic involvement diagnosed after histopathologic analysis of conjunctival deposits.
结节病是一种病因不明的炎症性疾病，其特征为非干酪样肉芽肿。在本研究中，作者报告了一例经结膜沉积物组织病理学分析确诊的无全身症状的结节病患者。
一名10岁女孩双侧球结膜出现局灶性、多叶状、多个淡黄色沉积物，持续一年。在患者的生物显微镜检查中，双侧球结膜均发现大量直径为0.50至2毫米的淡黄色沉积物。患者无其他全身或眼部不适症状。遂进行结膜活检。
活检标本显示非干酪样肉芽肿伴有明显的星状体。患者血清血管紧张素转换酶水平升高。结膜沉积物是该患者结节病的首发表现，结膜活检确诊为结节病。
据作者所知，这是第二项报道经结膜沉积物组织病理学分析后诊断为无全身受累的结节病患者的研究。
