Bastiaensen L A, Verpalen M C, Pijpers P M, Sprong A C
Doc Ophthalmol. 1985 Jan 31;59(1):5-9. doi: 10.1007/BF00162003.
A biopsy from the lower conjunctival fornix, whether or not taken from follicles, is a method which yields a positive result in +/- 25% of cases of suspected sarcoidosis. We saw a patient with chronic recurrent follicular conjunctivitis of the upper eyelid, without further ocular symptoms. He was known to suffer from allergy and chronic respiratory disease. As the conjunctivitis did not improve a biopsy was taken from the conjunctiva of the upper eyelid. The specimen showed non-necrotizing epithelioid-cell granulomata with multinucleate giant cells and asteroid bodies, and an increase in reticular fibres. The diagnosis of sarcoidosis was confirmed by finding parabronchial granulomata and a raised level of angiotensin-converting enzyme in the serum. Prolonged local corticoid therapy then gradually cleared up the conjunctival condition.
取自下结膜穹窿的活检组织，无论是否取自滤泡，在约25%的疑似结节病病例中都能得出阳性结果。我们接诊了一名患有上睑慢性复发性滤泡性结膜炎的患者，无其他眼部症状。已知他患有过敏和慢性呼吸道疾病。由于结膜炎未见好转，遂取上睑结膜进行活检。标本显示有非坏死性上皮样细胞肉芽肿，伴有多核巨细胞和星状体，网状纤维增多。通过发现支气管旁肉芽肿和血清中血管紧张素转换酶水平升高，确诊为结节病。随后长期局部使用皮质类固醇治疗，逐渐消除了结膜病变。
