一条通向病毒感染的超级高速公路。

A superhighway to virus infection.

作者信息

Greber Urs F, Way Michael

机构信息

Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

出版信息

Cell. 2006 Feb 24;124(4):741-54. doi: 10.1016/j.cell.2006.02.018.

DOI:10.1016/j.cell.2006.02.018

PMID:16497585

Abstract

Microtubule-mediated transport of macromolecules and organelles (also known as "cargo") is essential for cells to function. Deficiencies in cytoplasmic transport are frequently associated with severe diseases and syndromes. Cytoplasmic transport also provides viruses with the means to reach their site of replication and is the route for newly assembled progeny to leave the infected cell. This parasitic relationship of viruses with the host cytoskeleton provides an excellent basis for cell biologists to unlock the secrets of cytoplasmic transport and unravel mechanisms of disease. Recent advances in live cell imaging and computational tracking of fluorescently labeled viruses are now revealing how complex the movements of single viruses are in infected cells. This review focuses on microtubule-based motility of viruses and highlights the mechanisms regulating cytoplasmic transport.

摘要

微管介导的大分子和细胞器（也称为“货物”）运输对于细胞发挥功能至关重要。细胞质运输缺陷常与严重疾病和综合征相关。细胞质运输还为病毒提供了到达其复制位点的途径，并且是新组装的子代病毒离开受感染细胞的路线。病毒与宿主细胞骨架的这种寄生关系为细胞生物学家揭开细胞质运输的秘密和阐明疾病机制提供了绝佳基础。活细胞成像和荧光标记病毒的计算追踪方面的最新进展，正在揭示单个病毒在受感染细胞中的运动有多复杂。本综述聚焦于病毒基于微管的运动，并突出了调节细胞质运输的机制。