Bernstein D I, Sander D S, Smith V E, Schiff G M, Ward R L
Division of Clinical Virology, James N. Gamble Institute of Medical Research, Cincinnati, Ohio 45219.
J Infect Dis. 1991 Aug;164(2):277-83. doi: 10.1093/infdis/164.2.277.
To measure protection induced by natural rotavirus infection, 163 infants enrolled in a rotavirus vaccine trial were prospectively followed for 2 years. Serotype 1 rotaviruses were the predominant circulating strains during the study. Over the 2 years of observation, significantly fewer infants infected before enrollment developed a symptomatic reinfection (0 of 21) or any reinfection (4 of 21) compared with previously uninfected infants (P = .0003). Of the 60 infants who developed a primary rotavirus infection in the first year (40 symptomatic, 20 asymptomatic) only 4 were reinfected in the second year compared with 29 of 82 subjects not previously infected (P = .00003). Asymptomatic primary infection appeared to be as protective as symptomatic primary infection. The only symptomatic reinfections occurred in 2 subjects who did not develop rotavirus antibody after the initial detection of rotavirus. An age-related reduction in the ratio of symptomatic to asymptomatic primary rotavirus infection was also detected. In this study, protection against homotypic serotype 1 reinfection appeared to last greater than or equal to 2 years.
为了评估自然轮状病毒感染所诱导的保护作用，对参与轮状病毒疫苗试验的163名婴儿进行了为期2年的前瞻性随访。在研究期间，1型轮状病毒是主要的流行毒株。在2年的观察期内，与之前未感染的婴儿相比，入组前感染的婴儿出现有症状再感染（21例中0例）或任何再感染（21例中4例）的情况明显更少（P = 0.0003）。在第一年发生初次轮状病毒感染的60名婴儿中（40例有症状，20例无症状），第二年只有4例再次感染，而在82名之前未感染的婴儿中有29例再次感染（P = 0.00003）。无症状初次感染似乎与有症状初次感染具有同样的保护作用。仅有的有症状再感染发生在最初检测到轮状病毒后未产生轮状病毒抗体的2名受试者身上。还检测到有症状与无症状初次轮状病毒感染的比例随年龄增长而降低。在本研究中，针对同型1型再感染的保护作用似乎持续了2年或更长时间。
