马来西亚人对两株人类疱疹病毒6型的抗体反应性。

Antibody reactivity with two strains of human herpesvirus-6 in Malaysians.

作者信息

Yadav M, Umamaheswari S, Ablashi D

机构信息

Department of Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

J Med Virol. 1991 Apr;33(4):236-9. doi: 10.1002/jmv.1890330405.

DOI:10.1002/jmv.1890330405

PMID:1649908

Abstract

A total of 234 sera from healthy Malaysians of diverse ethnic origins were tested for antibody to the Z29 and prototype GS strains of HHV-6. The prevalence in the races ranged from 58 to 80% for the GS strain and 49 to 76% for the Z29 strain. The highest prevalence was in Malays with semi-urban cultural lifestyles and lowest was in the indigenous rural tribes (Ibans, Kadazans, Bidayuhs, and Orang Asli). The antibody titres to GS and Z29 virus capsid antigens differed in 11 (4.7%) samples by more than 2 dilutions. In 9 of the 11 sera the titres to GS strain were higher than to the Z29 strain. The differences in the antibody titres between strains of HHV-6 may reflect subtle changes in antigen structure of the virus recognised by some individuals.

摘要

对234份来自不同种族的健康马来西亚人的血清进行了检测，以检测其针对HHV-6的Z29株和原型GS株的抗体。各种族中GS株的流行率为58%至80%，Z29株的流行率为49%至76%。流行率最高的是具有半城市文化生活方式的马来人，最低的是土著农村部落（伊班人、卡达山人、比达友人以及原住民）。11份（4.7%）样本中针对GS和Z29病毒衣壳抗原的抗体滴度相差超过2倍稀释度。在这11份血清中的9份中，针对GS株的滴度高于Z29株。HHV-6各毒株之间抗体滴度的差异可能反映了一些个体所识别的病毒抗原结构的细微变化。