来自小花斜纹藻的细胞毒性二乙炔基螺缩酮烯醇醚。

Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus.

作者信息

Casu Laura, Bonsignore Leonardo, Pinna Manuela, Casu Mariano, Floris Costantino, Gertsch Jürg, Cottiglia Filippo

机构信息

Dipartimento Farmaco Chimico Tecnologico, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

出版信息

J Nat Prod. 2006 Feb;69(2):295-8. doi: 10.1021/np0504513.

DOI:10.1021/np0504513

PMID:16499337

Abstract

Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC(50) values ranging from 4 to 6 microM.

摘要

从小花斜翼（Plagius flosculosus）的叶子中分离出三种新的二乙炔基螺缩酮烯醇醚，分别命名为小花素A（1）、B（2）和C（3），以及五种相同结构类型的已知化合物（4 - 8）。通过广泛的一维和二维核磁共振光谱以及质谱对其结构进行了推导。所有分离出的化合物对白血病细胞（Jurkat T和HL - 60）均表现出显著的细胞毒性活性。化合物5 - 8在HL - 60细胞中诱导凋亡，相应的半数抑制浓度（IC50）值范围为4至6微摩尔。