Yokosuka Akihito, Jitsuno Maki, Yui Satoru, Yamazaki Masatoshi, Mimaki Yoshihiro
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.
J Nat Prod. 2009 Aug;72(8):1399-404. doi: 10.1021/np900168d.
Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.
从犹他龙舌兰的全株中分离出8种新的螺旋甾烷醇皂苷（1-8）和3种新的呋甾烷醇皂苷（9-11）。通过广泛的光谱数据分析确定了1-11的结构。评估了这些皂苷对HL-60人早幼粒细胞白血病细胞的细胞毒性活性。化合物1对HL-60细胞显示出细胞毒性，IC（50）值为4.9微克/毫升，诱导HL-60细胞凋亡，并显著激活caspase-3。
