来自犹他龙舌兰的甾体苷及其细胞毒性活性。
Steroidal glycosides from Agave utahensis and their cytotoxic activity.
作者信息
Yokosuka Akihito, Jitsuno Maki, Yui Satoru, Yamazaki Masatoshi, Mimaki Yoshihiro
机构信息
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.
出版信息
J Nat Prod. 2009 Aug;72(8):1399-404. doi: 10.1021/np900168d.
Eight new spirostanol saponins (1-8) and three new furostanol saponins (9-11) were isolated from the whole plants of Agave utahensis. The structures of 1-11 were determined by analysis of extensive spectroscopic data. The saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 showed cytotoxicity against HL-60 cells with an IC(50) value of 4.9 microg/mL, induced apoptosis in HL-60 cells, and markedly activated caspase-3.
从犹他龙舌兰的全株中分离出8种新的螺旋甾烷醇皂苷（1-8）和3种新的呋甾烷醇皂苷（9-11）。通过广泛的光谱数据分析确定了1-11的结构。评估了这些皂苷对HL-60人早幼粒细胞白血病细胞的细胞毒性活性。化合物1对HL-60细胞显示出细胞毒性，IC（50）值为4.9微克/毫升，诱导HL-60细胞凋亡，并显著激活caspase-3。
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