Geling N G, Klimenko T V, Milekhin G N
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(4):99-101.
A study was made of the activity of prostaglandin-synthetase in isolated platelets from the 2 groups of schizophrenic patients: with the predominance of positive (group I) and negative (group II) disorders. It has been demonstrated that the activity of prostaglandin-synthetase in isolated platelets from patients with hallucinatory delirium++ disorders is considerably higher (p less than 0.01) than the activity of prostaglandin-synthetase in isolated platelets from patients with the predominance of negative symptoms. The data obtained once more raise a question of the ++patho-chemical heterogeneity of schizophrenia, which also pertains to prostaglandins. The authors discuss a possibility of the relationship in schizophrenic patients between the regulatory system of prostaglandin synthesis and the central hypothalamohypophyseal mechanism by which homeostasis is regulated.
一组以阳性症状为主（第一组），另一组以阴性症状为主（第二组）。结果表明，有幻觉谵妄症状的患者分离出的血小板中前列腺素合成酶的活性显著高于（p<0.01）以阴性症状为主的患者分离出的血小板中前列腺素合成酶的活性。所获得的数据再次提出了精神分裂症病理化学异质性的问题，这也与前列腺素有关。作者讨论了精神分裂症患者中前列腺素合成调节系统与调节体内平衡的下丘脑 - 垂体中央机制之间存在关联的可能性。
