Arango C, Kirkpatrick B, Buchanan R W, Carpenter W T
Maryland Psychiatric Research Center, Medical School, University of Maryland, Baltimore, USA.
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1998 May-Jun;26(3):180-6.
Schizophrenia is a heterogeneous clinical syndrome and this variability may reflect differences in etiology and pathophysiology. Such heterogeneity could be responsible for the difficulties in research when all patients with schizophrenia are included in the same group. Subgroups of more clinical homogeneity are more likely to be homogeneous for the presumed pathophysiology of interest. Primary, enduring negative symptoms have been proposed to designate the deficit syndrome. The data obtained in the recent years and summarized in this review show that negative symptoms broadly defined are less effective for subgrouping schizophrenia and that the deficit syndrome is a different domain within schizophrenia.
精神分裂症是一种异质性临床综合征，这种变异性可能反映了病因学和病理生理学的差异。当所有精神分裂症患者被纳入同一组时，这种异质性可能导致研究困难。临床同质性更高的亚组在假定的相关病理生理学方面更有可能是同质的。原发性、持续性阴性症状被认为是缺陷综合征的特征。近年来获得并在本综述中总结的数据表明，广义定义的阴性症状对精神分裂症进行亚组划分的效果较差，且缺陷综合征是精神分裂症中的一个不同领域。
