不同类型青光眼患者的血清同型半胱氨酸、维生素B12和叶酸水平
Serum homocysteine, vitamin B 12 and folic acid levels in different types of glaucoma.
作者信息
Cumurcu Tongabay, Sahin Semsettin, Aydin Erdinc
机构信息
Department of Ophthalmology, Gaziosmanpasa University, School of Medicine, Tokat, Turkey.
出版信息
BMC Ophthalmol. 2006 Feb 23;6:6. doi: 10.1186/1471-2415-6-6.
BACKGROUND
This study was performed to compare levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with primary open-angle glaucoma (POAG), pseudoexfoliative glaucoma (PEXG), normotensive glaucoma (NTG) and healthy controls.
METHODS
Twenty-five patients with POAG, 24 with PEXG, and 18 with NTG, along with 19 control healthy subjects were included this prospective study. Levels of serum Hcy were measured using immunoassay, and those of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay.
RESULTS
The mean Hcy concentration in the PEXG group was significantly higher (P < 0.001) as compared to the other groups. There were no significant differences with respect to the mean Hcy concentrations among other groups (P > 0.05). There were no statistical differences in serum vitamin B12 levels among POAG, PEXG, NTG and control subjects (P > 0.05). The mean serum folic acid level was significantly lower in the subjects with PEXG (P < 0.009). However, the mean folic acid concentrations among the other groups did not differ significantly (P > 0.05).
CONCLUSION
Elevated levels of Hcy in PEXG may explain the role of endothelial dysfunction among patients with PEXG.
背景
本研究旨在比较原发性开角型青光眼（POAG）、剥脱性青光眼（PEXG）、正常眼压性青光眼（NTG）患者及健康对照者的血清同型半胱氨酸（Hcy）、维生素B12和叶酸水平。
方法
本前瞻性研究纳入了25例POAG患者、24例PEXG患者、18例NTG患者以及19例健康对照者。采用免疫分析法测定血清Hcy水平，采用竞争性化学发光酶免疫分析法测定血清维生素B12和叶酸水平。
结果
与其他组相比，PEXG组的平均Hcy浓度显著更高（P < 0.001）。其他组之间的平均Hcy浓度无显著差异（P > 0.05）。POAG、PEXG、NTG患者及对照者的血清维生素B12水平无统计学差异（P > 0.05）。PEXG患者的平均血清叶酸水平显著更低（P < 0.009）。然而，其他组之间的平均叶酸浓度无显著差异（P > 0.05）。
结论
PEXG患者中Hcy水平升高可能解释了PEXG患者内皮功能障碍的作用。
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