Jullian V, Bourdy G, Georges S, Maurel S, Sauvain M
Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR-152 IRD - Université Paul Sabatier, Centre IRD de Cayenne, BP 165, 97323 Cayenne, Guyane, France.
J Ethnopharmacol. 2006 Jul 19;106(3):348-52. doi: 10.1016/j.jep.2006.01.011. Epub 2006 Feb 28.
Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria. Bioassay-guided extractions of Zanthoxylum rhoifolium bark have shown that antiplasmodial activity is concentrated in the alkaloid fraction. Further fractionation of this extract has yielded seven benzophenanthridine alkaloids, dihydroavicine 1, dihydronitidine 2, oxyavicine 3, oxynitidine 4, fagaridine 5, avicine 6 and nitidine 7. Antimalarial activity of the last five compounds has been evaluated, and nitidine was the most potent, displaying an IC(50)<0.27microM against Plasmodium falciparum. Investigation of the traditional remedy, a trunk bark decoction in water, has shown that fagaridine 5, avicine 6 and nitidine 7 are also present in the decoction, therefore justifying the traditional use of Zanthoxylumrhoifolium bark as antimalarial.
刺叶花椒树皮（芸香科）是一种药用植物，在法属圭亚那传统上用于治疗和预防疟疾。对刺叶花椒树皮进行生物测定导向的提取表明，抗疟活性集中在生物碱部分。对该提取物进一步分离得到了七种苯并菲啶生物碱，即二氢阿维辛1、二氢尼替丁2、氧化阿维辛3、氧化尼替丁4、法加里定5、阿维辛6和尼替丁7。已对后五种化合物的抗疟活性进行了评估，其中尼替丁活性最强，对恶性疟原虫的IC（50）<0.27微摩尔。对传统疗法（树干树皮水煎剂）的研究表明，水煎剂中也存在法加里定5、阿维辛6和尼替丁7，因此证明了刺叶花椒树皮作为抗疟药的传统用途。
