Chabalko J J, Fraumeni J F
Dis Colon Rectum. 1975 Jan-Feb;18(1):1-3. doi: 10.1007/BF02587228.
Despite many similarities to colorectal cancer in adults, the rare childhood form has some peculiarities. Childhood mortality is greater among Negroes than Caucasians, particularly in boys, reflecting the rising incidence of this tumor in the young Negro population. In addition, the percentage of childhood cases with precancerous diseases (polyposis, colitis) appears greater than in adults. Most striking is the high percentage of mucin-producing tumors in young people with colorectal cancer. The mucoid tumors tend to occur after the age of 10 years, whereas younger children are more likely to develop non-mucoid carcinoma in an adenomatous polyp.
尽管儿童结直肠癌与成人结直肠癌有许多相似之处，但这种罕见的儿童形式有一些独特之处。黑人儿童的死亡率高于白人儿童，尤其是男孩，这反映出这种肿瘤在年轻黑人人群中的发病率不断上升。此外，儿童患癌前疾病（息肉病、结肠炎）的比例似乎高于成人。最显著的是，患有结直肠癌的年轻人中产生黏液的肿瘤比例很高。黏液样肿瘤往往在10岁以后出现，而年幼儿童更有可能在腺瘤性息肉中发展为非黏液性癌。
