Okuno M, Ikehara T, Nagayama M, Sakamoto K, Kato Y, Umeyama K
Am J Surg. 1987 Sep;154(3):264-8. doi: 10.1016/0002-9610(89)90606-5.
Charts of 570 patients with colorectal carcinoma surgically treated in one institution during a 13 year period were retrospectively reviewed to evaluate clinicopathologic patterns and surgical results of those 39 years of age or under. Of the 570 patients, 57 (10 percent) were 39 years of age or under, and this group included more female patients than the older control group. Mucinous carcinoma was frequently found on histologic examination, with significantly high incidences of lymph node involvement, peritoneal dissemination, and advanced tumor stages by Dukes' classification in the young patients. The overall cumulative 5 year survival rate in the younger group was significantly lower than that in the control group (41 percent and 55.9 percent, respectively), whereas the difference in rates among the two groups for curative resection was not statistically significant (71.6 percent and 76.3 percent, respectively). Early diagnosis and attempts at curative resection are of utmost importance in the treatment of young patients with colorectal carcinoma.
回顾性分析了某机构13年间接受手术治疗的570例结直肠癌患者的病历，以评估39岁及以下患者的临床病理特征和手术结果。在这570例患者中，57例（10%）年龄在39岁及以下，该组女性患者多于年龄较大的对照组。组织学检查经常发现黏液腺癌，年轻患者的淋巴结受累、腹膜播散和根据杜克分类法的晚期肿瘤阶段的发生率显著较高。较年轻组的总体累积5年生存率显著低于对照组（分别为41%和55.9%），而两组间根治性切除率的差异无统计学意义（分别为71.6%和76.3%）。早期诊断和根治性切除尝试对年轻结直肠癌患者的治疗至关重要。
