Dajani Y F, Zayid I, Malatjalian D A, Kamal M F
Cancer. 1980 Jul 15;46(2):420-8. doi: 10.1002/1097-0142(19800715)46:2<420::aid-cncr2820460236>3.0.co;2-1.
A comparative study of colorectal adenocarcinoma was undertaken among the populations of Jordan and Nova Scotia, Canada. The incidence of this cancer was 13 (colon 6, rectum 7) and 53 (colon 31, rectum 22) per 100,000 males aged 35--64 years, respectively. Colonic tumors (excluding rectosigmoid) showed left-sided preponderance in Jordanians and right-sided preponderance in Nova Scotians. Age average at diagnosis was 49 years in Jordanians (colon 47 years and rectum 50 years) and 66 years in Nova Scotians (colon 67 years and rectum 63 years), with peaks in the fifth and seventh decades and a male to female ratio of 1.3:1 and 1:1, respectively. The mucinous type accounted for 31 and 13% of colorectal adenocarcinomas in Jordanians and Nova Scotians, respectively, of which the signet-cell type accounted for 14 and 2% of the total number, respectively. The actual incidence rate of mucinous carcinoma, however, was higher among Nova Scotians. In both groups, mucinous carcinoma showed predilection for females and rectal signet-cell carcinoma showed bias toward younger females. The authors believe that the significantly different epidemiologic and morphologic features of colorectal cancer demonstrated in these two communities could shed light on possible etiologic influences, such as dietary habits or other environmental factors.
在约旦和加拿大新斯科舍省的人群中开展了一项结直肠癌的对比研究。在35至64岁的男性中，这种癌症的发病率分别为每10万人中有13例（结肠癌6例，直肠癌7例）和53例（结肠癌31例，直肠癌22例）。结肠肿瘤（不包括直肠乙状结肠）在约旦人当中以左侧居多，而在新斯科舍人当中以右侧居多。约旦人诊断时的平均年龄为49岁（结肠癌47岁，直肠癌50岁），新斯科舍人则为66岁（结肠癌67岁，直肠癌63岁），发病高峰分别在第五和第七个十年，男女比例分别为1.3:1和1:1。黏液型在约旦人和新斯科舍人的结直肠癌中分别占31%和13%，其中印戒细胞型分别占总数的14%和2%。然而，黏液癌的实际发病率在新斯科舍人当中更高。在两组中，黏液癌均显示出对女性的偏好，而直肠印戒细胞癌则偏向于年轻女性。作者认为，这两个群体中所显示的结直肠癌在流行病学和形态学上的显著差异，可能有助于揭示诸如饮食习惯或其他环境因素等潜在的病因影响。
