Whitaker S B, Waldron C A
Department of Oral Pathology, West Virginia University School of Dentistry, Morgantown.
Oral Surg Oral Med Oral Pathol. 1993 Feb;75(2):199-208. doi: 10.1016/0030-4220(93)90094-k.
The histology, radiographs, and follow-up information for 142 cases of central giant cell lesions of the jaws were reviewed in an effort to determine which, if any, microscopic features could be correlated with clinical behavior. The majority of these lesions were asymptomatic and relatively innocuous. However, some displayed a more aggressive clinical course characterized by root resorption, pain or paresthesia, and cortical perforation. The over-all recurrence rate in the 142 cases was 16%. Adequate follow-up information (mean, 48 months) was only obtained for 47 patients, and 23 (46%) of these experienced one or more recurrences. Statistically significant histologic differences in distribution of giant cells and frequency of osteoid within the lesions were found in lesions that recurred as opposed to those that did not. The concept that giant cell lesions of the jaws are not totally different entities from giant cell tumors is discussed.
回顾了142例颌骨中心性巨细胞病变的组织学、X线片及随访信息，以确定是否有任何微观特征与临床行为相关。这些病变大多数无症状且相对无害。然而，一些病变表现出更具侵袭性的临床过程，其特征为牙根吸收、疼痛或感觉异常以及皮质穿孔。142例患者的总体复发率为16%。仅47例患者获得了充分的随访信息（平均48个月），其中23例（46%）经历了一次或多次复发。与未复发的病变相比，复发病变在巨细胞分布和病变内类骨质频率方面存在统计学上显著的组织学差异。文中还讨论了颌骨巨细胞病变与巨细胞瘤并非完全不同实体的概念。
