[中国山东省临朐县和禹城市脊髓灰质炎病毒中和抗体的血清流行病学调查]

[A seroepidemiological survey of neutralization antibodies to polioviruses in Linqu and Yucheng counties of Shandong Province, China].

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1991 Jun;12(3):146-9.

Abstract

Two hundred and fifty two serum samples from Linqu county and 249 serum samples from Yucheng county, in Shandong province, China, were collected among the age group of 0-, 1-, 2-, 3- and 5-9 years old and assayed by microneutralization test in 1989. The results showed that the positive rates (PRs) and geometric mean titres (GMTs) of antibodies to poliovirus type 1-3 in Linqu county were 82.54%, 80.56%, 82.94% and 27.06, 22.94, 24.24, respectively, and much significantly higher than those, in Yucheng county (84.34%, 51.81%, 59.04% and 16.78, 2.79, 3.40) except the PR to typel.for children in both countries, the PRs and GMTs were highest in the age group of 2-4 years old, and no significant difference was found between male and female. All above indicated that EPI was helpful for improving immune status of children, the coverage of TOPV and quality of vaccination should still be emphasized in future EPI works.

摘要

1989年，在中国山东省，采集了临朐县252份血清样本和禹城县249份血清样本，样本来自0岁、1岁、2岁、3岁以及5 - 9岁年龄组，并通过微量中和试验进行检测。结果显示，临朐县1 - 3型脊髓灰质炎病毒抗体阳性率（PRs）和几何平均滴度（GMTs）分别为82.54%、80.56%、82.94%以及27.06、22.94、24.24，除1型病毒抗体阳性率外，均显著高于禹城县（84.34%、51.81%、59.04%以及16.78、2.79、3.40）。对于两个县的儿童，阳性率和几何平均滴度在2 - 4岁年龄组最高，且男女之间无显著差异。以上所有结果表明，扩大免疫规划有助于提高儿童免疫状况，在未来的扩大免疫规划工作中仍应强调三价口服脊髓灰质炎减毒活疫苗（TOPV）的接种覆盖率和接种质量。