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纳米技术——对抗抗生素耐药性的希望之光。

Nanotechnology-A Light of Hope for Combating Antibiotic Resistance.

作者信息

Muteeb Ghazala

机构信息

Department of Nursing, College of Applied Medical Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

出版信息

Microorganisms. 2023 Jun 3;11(6):1489. doi: 10.3390/microorganisms11061489.

Abstract

Antibiotic usage and resistance are major health concerns. Antibiotic resistance occurs when bacteria evolve to resist the effects of antibiotics, making it impossible to treat infections. The overuse and misuse of antibiotics are the main contributing factors, while environmental stress (such as heavy metals accumulation), unhygienic conditions, illiteracy, and unawareness also contribute to antibiotic resistance. The slow and costly development of new antibiotics has lagged behind the emergence of antibiotic-resistant bacteria, and the overuse of antibiotics leads to negative consequences. The current study used different literature resources to generate an opinion and find a possible solution to antibiotic barriers. Different scientific approaches have been reported to overcome antibiotic resistance. The most useful approach among these is nanotechnology. Nanoparticles can be engineered to disrupt bacterial cell walls or membranes, effectively eliminating resistant strains. Additionally, nanoscale devices enable the real-time monitoring of bacterial populations, allowing for the early detection of resistance emergence. Nanotechnology, along with evolutionary theory offers promising avenues in combating antibiotic resistance. Evolutionary theory helps us understand the mechanisms by which bacteria develop resistance, allowing us to anticipate and counteract their adaptive strategies. By studying the selective pressures that drive resistance, we can therefore design more effective interventions or traps. The synergy between the evolutionary theory and nanotechnology presents a powerful approach to combat antibiotic resistance, offering new avenues for the development of effective treatments and the preservation of our antibiotic arsenal.

摘要

抗生素的使用和耐药性是主要的健康问题。当细菌进化出对抗生素作用的抗性时,就会出现抗生素耐药性,从而使感染无法得到治疗。抗生素的过度使用和滥用是主要促成因素,而环境压力(如重金属积累)、不卫生条件、文盲和意识淡薄也会导致抗生素耐药性。新抗生素研发缓慢且成本高昂,落后于耐药细菌的出现,抗生素的过度使用会带来负面后果。当前的研究利用不同的文献资源形成一种观点,并找到解决抗生素障碍的可能办法。据报道,有多种科学方法可克服抗生素耐药性。其中最有用的方法是纳米技术。可以设计纳米颗粒来破坏细菌细胞壁或细胞膜,有效消除耐药菌株。此外,纳米级设备能够实时监测细菌种群,以便早期发现耐药性的出现。纳米技术与进化理论为对抗抗生素耐药性提供了有前景的途径。进化理论帮助我们理解细菌产生耐药性的机制,使我们能够预测并对抗它们的适应性策略。通过研究驱动耐药性的选择压力,我们因此可以设计出更有效的干预措施或陷阱。进化理论与纳米技术之间的协同作用提供了一种强大的对抗抗生素耐药性的方法,为开发有效治疗方法和保护我们的抗生素库提供了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be10/10302692/dd881e263317/microorganisms-11-01489-g001.jpg

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