Campese Antonio F, Garbe Annette I, Zhang Fangrong, Grassi Fabio, Screpanti Isabella, von Boehmer Harald
Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Blood. 2006 Jul 1;108(1):305-10. doi: 10.1182/blood-2006-01-0143. Epub 2006 Feb 28.
Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.
细胞内Notch的过表达在人类急性淋巴细胞性T细胞白血病（T-ALL）的发生中起重要作用。在小鼠模型中，已表明Notch依赖性T-ALL需要前T细胞受体（pre-TCR）信号传导。在此我们表明，pre-TCR信号传导是使小鼠适应Notch依赖性转化所必需的，但维持T-ALL的恶性生长并不需要它。与先前的研究相反，我们发现疾病发展不需要pre-TCR，但通过短暂模拟pre-TCR信号，它可以在Rag2(-/-)小鼠中加速。
