Kuan James K, Wright Jonathan L, Nathens Avery B, Rivara Frederick P, Wessells Hunter
Department of Urology, University of Washington Medical Center, Seattle, Washington 98104, USA.
J Trauma. 2006 Feb;60(2):351-6. doi: 10.1097/01.ta.0000202509.32188.72.
Despite broad clinical use of the American Association of the Surgery of Trauma (AAST) injury scale for kidney, it has only been found to predict the need for renal surgery in single institution series. We sought to validate this scheme for morbidity and mortality in a national cohort of patients with renal injury.
A retrospective cohort design was used to determine the association between increasing AAST scores and nephrectomy, dialysis, and mortality. The cohort included all patients with a renal injury in the National Trauma Data Bank (NTDB) from 1994 and 2003. Univariate and multivariate prediction models were used for analysis of data.
At the time of review, a total of 742,774 patient records were registered in the NTDB. Renal injury occurred in 8465 patients (1.2%). Increasing injury grade was associated with a greater nephrectomy (RR 12-127), dialysis (RR 1.3-4.7), and mortality (RR 1.3-1.9) rate for blunt kidney injury. For penetrating injury, nephrectomy was the only outcome that was associated with higher grades of renal injury with a RR of 7.7 to 31 for grades III to V injuries.
The AAST injury scale for kidney predicts for morbidity in blunt and penetrating renal injury and for mortality in blunt injury. Thus, we continue to support its use as a clinical and research tool.
尽管美国创伤外科协会(AAST)肾脏损伤分级在临床上广泛应用,但仅在单一机构系列研究中发现其可预测肾脏手术需求。我们试图在全国性肾损伤患者队列中验证该分级方案对发病率和死亡率的预测价值。
采用回顾性队列设计来确定AAST评分增加与肾切除术、透析及死亡率之间的关联。该队列包括1994年至2003年国家创伤数据库(NTDB)中所有肾损伤患者。使用单变量和多变量预测模型进行数据分析。
在审查时,NTDB共登记了742,774份患者记录。8465例患者(1.2%)发生肾损伤。损伤分级增加与钝性肾损伤的肾切除率(相对风险12 - 127)、透析率(相对风险1.3 - 4.7)和死亡率(相对风险1.3 - 1.9)升高相关。对于穿透性损伤,肾切除术是唯一与较高等级肾损伤相关的结局,Ⅲ至Ⅴ级损伤的相对风险为7.7至31。
AAST肾脏损伤分级可预测钝性和穿透性肾损伤的发病率以及钝性损伤的死亡率。因此,我们继续支持将其用作临床和研究工具。