Nordwall Maria, Hyllienmark Lars, Ludvigsson Johnny
Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, University Hospital, Linköping, Sweden.
J Pediatr Endocrinol Metab. 2006 Jan;19(1):45-54. doi: 10.1515/jpem.2006.19.1.45.
To describe the prevalence of early complications in an unselected population of patients with type 1 diabetes mellitus (DM1) diagnosed in childhood with intensive insulin treatment from diagnosis.
Eighty children and adolescents with DM1, age 7-22 years and DM1 duration >3 years, were studied. Neuropathy was defined as abnormal nerve conduction finding in > or = 2 of 4 nerves (sural and peroneal nerves), nephropathy as albumin excretion rate > or = 20 microg/min and retinopathy as all grades of retinal changes in fundus photographs.
The prevalence of neuropathy was 59%, of retinopathy 27% and of nephropathy 5% after 13 years DM1 duration. Mean (SD) long-term HbA1c was 8.4 (0.9)% (DCCT-corrected value).
Even in a population with intensive insulin treatment from the beginning and fairly good metabolic control, the prevalence of subclinical neuropathy was high, while other diabetic complications were lower than usually reported.
描述一组未经筛选的1型糖尿病（DM1）患儿自诊断起接受强化胰岛素治疗后的早期并发症患病率。
对80名年龄在7 - 22岁、DM1病程超过3年的DM1患儿及青少年进行研究。神经病变定义为4条神经（腓肠神经和腓总神经）中至少2条神经传导检查异常；肾病定义为白蛋白排泄率≥20微克/分钟；视网膜病变定义为眼底照片中出现各级视网膜改变。
DM1病程13年后，神经病变患病率为59%，视网膜病变患病率为27%，肾病患病率为5%。长期糖化血红蛋白（HbA1c）平均（标准差）为8.4（0.9）%（糖尿病控制与并发症试验[DCCT]校正值）。
即使是从一开始就接受强化胰岛素治疗且代谢控制相当良好的人群，亚临床神经病变的患病率仍很高，而其他糖尿病并发症的患病率低于通常报道。
