Torabinezad Simin, Kumar Perikala V, Hashemi Seyed Baseer, Rahimi Abbass
Department of Pathology, Shiraz Medical School and Cancer Research Institute, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Acta Cytol. 2006 Jan-Feb;50(1):80-3. doi: 10.1159/000325899.
Osteoclastomalike giant cell tumor of the parotid gland has been reported rarely. The tumor has occurred rarely at many sites, such as thyroid, pancreas, soft tissue, breast, skin, heart, colon, lung, kidney, ovary and bladder. The exact origin of the tumor is unclear. However, osteoclastlike giant cells have been considered either part of a stromal process reactive to a neoplasm or a component of a primary neoplasm.
A 35-year-old female presented with a mass in the left parotid gland clinically diagnosed as a pleomorphic adenoma. Fine needle aspiration (FNA) was advised before surgical excision. FNA smears revealed numerous osteoclastlike, multinucleated giant cells and many malignant-looking mononuclear cells. The smears were diagnosed as positive for malignancy, suggestive of osteoclastomalike giant cell tumor. The tumor was excised, and histopathologic study confirmed the cytologic diagnosis.
The cytologic findings of osteoclastomalike giant cell tumor of the parotid gland have not been previously reported. FNA aided the diagnosis and planning of treatment. FNA is important in the diagnosis of parotid tumors.
腮腺破骨细胞样巨细胞瘤鲜有报道。该肿瘤在许多部位都很少见，如甲状腺、胰腺、软组织、乳腺、皮肤、心脏、结肠、肺、肾、卵巢和膀胱。肿瘤的确切起源尚不清楚。然而，破骨细胞样巨细胞被认为要么是对肿瘤反应性的间质过程的一部分，要么是原发性肿瘤的一个组成部分。
一名35岁女性，左侧腮腺出现肿块，临床诊断为多形性腺瘤。建议在手术切除前进行细针穿刺抽吸（FNA）。FNA涂片显示有大量破骨细胞样多核巨细胞和许多形态可疑的单核细胞。涂片诊断为恶性阳性，提示破骨细胞样巨细胞瘤。肿瘤被切除，组织病理学研究证实了细胞学诊断。
腮腺破骨细胞样巨细胞瘤的细胞学表现此前未见报道。FNA有助于诊断和治疗方案的制定。FNA在腮腺肿瘤的诊断中很重要。
