Dana M Reza
Schepens Eye Research Institute and the Massachusetts Eye & Ear Infirmary, Harvard Department of Ophthalmology, Boston, MA, USA.
Semin Ophthalmol. 2006 Jan-Mar;21(1):19-22. doi: 10.1080/08820530500509358.
It is now widely acknowledged that vasculogenesis and immunogenic inflammation are intricately related in many tissues. However, less understood is to what extent blood (heme) angiogenesis (HA) and lymphangiogenesis (LG) are differentially regulated, and in turn contribute potentially to different aspects of adaptive immunity generated to corneal antigens. Herein, we will provide a brief synopsis of relevant work in this field by focusing particularly on the differential regulation of immunity by these two distinct vasculogenic processes in the cornea, illustrating that in spite of significant redundancies in the mechanisms that induce these vascular processes in the cornea, there are also important distinctions in what aspects of immunity are promoted by them.
目前人们普遍认识到，血管生成与免疫原性炎症在许多组织中密切相关。然而，对于血液（血红素）血管生成（HA）和淋巴管生成（LG）在何种程度上受到不同调节，以及它们如何反过来潜在地影响针对角膜抗原产生的适应性免疫的不同方面，人们了解较少。在此，我们将特别关注角膜中这两种不同血管生成过程对免疫的差异调节，简要概述该领域的相关工作，说明尽管在角膜中诱导这些血管生成过程的机制存在显著冗余，但它们在促进免疫的哪些方面也存在重要差异。
