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1
Insertion sequence IS900 revisited.插入序列IS900再探讨。
J Clin Microbiol. 2006 Mar;44(3):1081-3. doi: 10.1128/JCM.44.3.1081-1083.2006.
2
PCR-restriction endonuclease analysis for identification and strain typing of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium based on polymorphisms in IS1311.基于IS1311多态性的聚合酶链反应-限制性内切酶分析用于鸟分枝杆菌副结核亚种和鸟分枝杆菌亚种的鉴定及菌株分型
Mol Cell Probes. 1999 Apr;13(2):115-26. doi: 10.1006/mcpr.1999.0227.
3
High genetic diversity among Mycobacterium avium subsp. paratuberculosis strains from German cattle herds shown by combination of IS900 restriction fragment length polymorphism analysis and mycobacterial interspersed repetitive unit-variable-number tandem-repeat typing.通过IS900限制性片段长度多态性分析与分枝杆菌散布重复单位可变数目串联重复序列分型相结合显示，德国牛群中副结核分枝杆菌菌株间存在高度遗传多样性。
J Clin Microbiol. 2008 Mar;46(3):972-81. doi: 10.1128/JCM.01801-07. Epub 2008 Jan 3.
4
New variable-number tandem-repeat markers for typing Mycobacterium avium subsp. paratuberculosis and M. avium strains: comparison with IS900 and IS1245 restriction fragment length polymorphism typing.用于鸟分枝杆菌副结核亚种和鸟分枝杆菌菌株分型的新型可变数目串联重复序列标记：与IS900和IS1245限制性片段长度多态性分型的比较
J Clin Microbiol. 2007 Aug;45(8):2404-10. doi: 10.1128/JCM.00476-07. Epub 2007 May 30.
5
An IS900-like sequence found in a Mycobacterium sp. other than Mycobacterium avium subsp. paratuberculosis.在鸟分枝杆菌副结核亚种以外的一种分枝杆菌中发现的一个类似IS900的序列。
FEMS Microbiol Lett. 2002 Apr 9;209(2):267-71. doi: 10.1111/j.1574-6968.2002.tb11142.x.
6
Polymorphisms in IS1311, an insertion sequence common to Mycobacterium avium and M. avium subsp. paratuberculosis, can be used to distinguish between and within these species.IS1311（一种鸟分枝杆菌和副结核分枝杆菌亚种共有的插入序列）中的多态性可用于区分这些菌种以及同一菌种内的不同菌株。
Mol Cell Probes. 1998 Dec;12(6):349-58. doi: 10.1006/mcpr.1998.0194.
7
Short-sequence-repeat analysis of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium isolates collected from animals throughout the United States reveals both stability of loci and extensive diversity.对从美国各地动物身上分离出的副结核分枝杆菌亚种和鸟分枝杆菌亚种进行短串联重复序列分析，结果显示基因座既具有稳定性又具有广泛的多样性。
J Clin Microbiol. 2006 Aug;44(8):2970-3. doi: 10.1128/JCM.00584-06.
8
Genomic diversity in Mycobacterium avium: single nucleotide polymorphisms between the S and C strains of M. avium subsp. paratuberculosis and with M. a. avium.鸟分枝杆菌的基因组多样性：副结核分枝杆菌亚种S株和C株之间以及与鸟分枝杆菌之间的单核苷酸多态性
Mol Cell Probes. 2007 Feb;21(1):66-75. doi: 10.1016/j.mcp.2006.08.002. Epub 2006 Aug 30.
9
Distribution of IS1311 and IS1245 in Mycobacterium avium subspecies revisited.再次探讨IS1311和IS1245在鸟分枝杆菌亚种中的分布
J Clin Microbiol. 2005 May;43(5):2500-2. doi: 10.1128/JCM.43.5.2500-2502.2005.
10
Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease.在患有和未患有克罗恩病的个体的新鲜回结肠黏膜活检标本中检测和验证副结核分枝杆菌。
J Clin Microbiol. 2003 Jul;41(7):2915-23. doi: 10.1128/JCM.41.7.2915-2923.2003.

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Appl Environ Microbiol. 2023 Feb 28;89(2):e0168222. doi: 10.1128/aem.01682-22. Epub 2023 Jan 31.
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Serological investigation and genotyping of Mycobacterium avium subsp. paratuberculosis in sheep and goats in Inner Mongolia, China.中国内蒙古绵羊和山羊中分支杆菌副结核亚种的血清学调查和基因分型。
PLoS One. 2021 Sep 7;16(9):e0256628. doi: 10.1371/journal.pone.0256628. eCollection 2021.
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Whole-Genome Analysis of subsp. IS -.亚种IS - 的全基因组分析。 （你提供的原文似乎不太完整准确，这是尽力根据现有内容翻译的结果 ）
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Serological and Molecular Characterization of Subsp. (MAP) from Sheep, Goats, Cattle and Camels in the Eastern Province, Saudi Arabia.沙特阿拉伯东部省份绵羊、山羊、牛和骆驼中副结核分枝杆菌亚种（MAP）的血清学和分子特征分析
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Genetic Diversity Among Subspecies Revealed by Analysis of Complete Genome Sequences.通过全基因组序列分析揭示的亚种间遗传多样性
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Vet Rec. 2019 Jan 12;184(2):65. doi: 10.1136/vr.105085. Epub 2018 Dec 22.
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本文引用的文献

1
Differentiating host-associated variants of Mycobacterium avium by PCR for detection of large sequence polymorphisms.通过聚合酶链反应（PCR）区分鸟分枝杆菌的宿主相关变体以检测大序列多态性。
J Clin Microbiol. 2006 Mar;44(3):881-7. doi: 10.1128/JCM.44.3.881-887.2006.
2
Sequencing of hsp65 distinguishes among subsets of the Mycobacterium avium complex.hsp65基因测序可区分鸟分枝杆菌复合群的各个亚群。
J Clin Microbiol. 2006 Feb;44(2):433-40. doi: 10.1128/JCM.44.2.433-440.2006.
3
IS900-PCR-based detection and characterization of Mycobacterium avium subsp. paratuberculosis from buffy coat of cattle and sheep.基于IS900-PCR的牛和绵羊血沉棕黄层中副结核分枝杆菌亚种的检测与鉴定
Vet Microbiol. 2006 Jan 10;112(1):33-41. doi: 10.1016/j.vetmic.2005.10.004. Epub 2005 Nov 21.
4
The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.副结核分枝杆菌鸟分枝杆菌亚种的全基因组序列
Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12344-9. doi: 10.1073/pnas.0505662102. Epub 2005 Aug 22.
5
Genomic polymorphisms for Mycobacterium avium subsp. paratuberculosis diagnostics.用于副结核分枝杆菌诊断的基因组多态性
J Clin Microbiol. 2005 Aug;43(8):3704-12. doi: 10.1128/JCM.43.8.3704-3712.2005.
6
Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia.从撒丁岛克罗恩病患者和非克罗恩病患者的肠道黏膜活检样本中检测和分离副结核分枝杆菌鸟亚种。
Am J Gastroenterol. 2005 Jul;100(7):1529-36. doi: 10.1111/j.1572-0241.2005.41415.x.
7
High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease.克罗恩病患者肠道组织中鸟分枝杆菌副结核亚种IS900 DNA的高流行率。
Gut. 2005 Jul;54(7):944-9. doi: 10.1136/gut.2004.045526.
8
Detection of Mycobacterium avium subsp. paratuberculosis in intestinal and lymph node tissues of water buffaloes (Bubalus bubalis) by PCR and bacterial culture.通过聚合酶链反应（PCR）和细菌培养检测水牛（Bubalus bubalis）肠道和淋巴结组织中的副结核分枝杆菌。
Vet Microbiol. 2005 Jul 1;108(3-4):263-70. doi: 10.1016/j.vetmic.2005.04.002.
9
Mycobacterium avium subsp. paratuberculosis in the catchment area and water of the River Taff in South Wales, United Kingdom, and its potential relationship to clustering of Crohn's disease cases in the city of Cardiff.英国南威尔士塔夫河流域及河水当中的副结核分枝杆菌，及其与加的夫市克罗恩病病例聚集的潜在关系。
Appl Environ Microbiol. 2005 Apr;71(4):2130-9. doi: 10.1128/AEM.71.4.2130-2139.2005.
10
Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.从克罗恩病患者血液中培养副结核分枝杆菌鸟亚种。
Lancet. 2004;364(9439):1039-44. doi: 10.1016/S0140-6736(04)17058-X.

插入序列IS900再探讨。

Insertion sequence IS900 revisited.

作者信息

Semret Makeda, Turenne Christine Y, Behr Marcel A

机构信息

McGill University Health Center, Montreal, Quebec, Canada.

出版信息

J Clin Microbiol. 2006 Mar;44(3):1081-3. doi: 10.1128/JCM.44.3.1081-1083.2006.

DOI:10.1128/JCM.44.3.1081-1083.2006
PMID:16517898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1393169/
Abstract

Many studies investigating Mycobacterium avium subsp. paratuberculosis in Crohn's disease have used molecular detection of IS900 in clinical samples, but some have described polymorphisms in IS900 as variants of this organism. Analysis of 23 M. avium subsp. paratuberculosis isolates revealed that IS900 is highly conserved, with only two sequevars distinguishing sheep and cattle lineages. Amplification of IS900-like sequences is not sufficient as a proxy for M. avium subsp. paratuberculosis.

摘要

许多针对克罗恩病中副结核分枝杆菌的研究，在临床样本中使用了IS900的分子检测方法，但一些研究将IS900中的多态性描述为该生物体的变体。对23株副结核分枝杆菌分离株的分析表明，IS900高度保守，只有两个序列型可区分绵羊和牛的谱系。IS900样序列的扩增不足以作为副结核分枝杆菌的替代指标。