Chin N X, Neu H C
Department of Medicine, College of Physicians and Surgeons, New York, New York.
Diagn Microbiol Infect Dis. 1991 Mar-Apr;14(2):181-4. doi: 10.1016/0732-8893(91)90056-l.
LY264826 a new naturally occurring glycopeptide inhibited 90% of methicillin-susceptible and -resistant Staphylococcus aureus at 1 micrograms/ml. LY264826 had similar activity against methicillin-susceptible and -resistant coagulase-negative staphylococci. The LY264826 MIC90 for Streptococcus pyogenes was 0.25 microgram/ml, twofold more active than vancomycin and twofold less active than teicoplanin. LY264826 was eightfold more active than vancomycin and twofold more active than teicoplanin against enterococci. LY264826 inhibited Streptococcus pneumoniae at 0.25 microgram/ml and Listeria monocytogenes at 0.5 microgram/ml. Clostridium were inhibited by less than or equal to 0.25 microgram/ml of LY264826 and peptococci, peptostreptococci, and Fusobacterium were inhibited by less than 0.5 microgram/ml. Bacteroides species were LY284826 -resistant as were all Enterobacteriaceae, Flavobacterium, and Neisseria spp. Minimum bactericidal and inhibitory concentrations (MBCs and MICs) were within a dilution for S. aureus, S. pyogenes, and S. pneumoniae, but greater than or equal to 32-fold greater for enterococci.
LY264826是一种新的天然存在的糖肽，在浓度为1微克/毫升时可抑制90%的甲氧西林敏感和耐药金黄色葡萄球菌。LY264826对甲氧西林敏感和耐药的凝固酶阴性葡萄球菌具有相似的活性。化脓性链球菌的LY264826最低抑菌浓度（MIC90）为0.25微克/毫升，其活性比万古霉素高两倍，比替考拉宁低两倍。LY264826对肠球菌的活性比万古霉素高八倍，比替考拉宁高二倍。LY264826在浓度为0.25微克/毫升时可抑制肺炎链球菌，在浓度为0.5微克/毫升时可抑制单核细胞增生李斯特菌。梭菌被浓度小于或等于0.25微克/毫升的LY264826抑制，消化球菌、消化链球菌和梭杆菌被浓度小于0.5微克/毫升的LY264826抑制。拟杆菌属以及所有肠杆菌科细菌、黄杆菌属和奈瑟菌属对LY284826耐药。金黄色葡萄球菌、化脓性链球菌和肺炎链球菌的最低杀菌浓度和最低抑菌浓度（MBCs和MICs）在一个稀释度范围内，但肠球菌的MBCs和MICs比其高32倍或更高。
