Jiamjarasrangsi Wiroj, Aekplakorn Wichai
Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Med Assoc Thai. 2005 Dec;88(12):1896-904.
To determine the incidence rates of type 2 diabetes and associated factors among professional and office workers in Bangkok.
Data on fasting glucose measurements and physical examination were obtained from a cohort of 6,924 workers in 43 establishments in Bangkok during 1999-2003. Impaired fasting glucose and diabetes were defined according to the American Diabetes Association criteria. The type 2 diabetes incidence rates were calculated based on the person-time of follow-up period.
A total of 136 individuals developed type 2 diabetes during 11,581 person-years (py) of follow-up. The incidence rates of type 2 diabetes in individuals aged 35-60 years was 11.4 per 1000 py Men had a higher incidence rate than women (17.8 vs 9.2 per 1,000 py). The incidence rates increased with age. Factors associated with development of diabetes included baseline fasting plasma glucose (FPG) level, overweight and obesity status. Adjusted incidence rate ratios (IRR, 95%CI) for FPG of 93-99 mg/dl and 100-125 mg/dl were 3.2 [1.1-9.9] and 31.5 [11.4-86.8] respectively, compared to those with FPG < 93 mg/dl. The IRRs for those with BMI of 23-27.5 and > 27.5 kg/m2 were 1.5 [0.9-2.5] and 2.7 [1.6-4.5] respectively, compared to those with BMI < 23 kg/m2.
Findings from the present study could serve as the first marking post for estimating the risk and magnitude of type 2 diabetes in other adult populations in Thailand.
确定曼谷专业人员和办公室职员2型糖尿病的发病率及相关因素。
1999年至2003年期间，从曼谷43家机构的6924名工人队列中获取空腹血糖测量数据和体格检查数据。空腹血糖受损和糖尿病根据美国糖尿病协会标准定义。2型糖尿病发病率根据随访期的人时计算。
在11581人年的随访期间，共有136人患2型糖尿病。35至60岁个体的2型糖尿病发病率为每1000人年11.4例。男性发病率高于女性（每1000人年17.8例对9.2例）。发病率随年龄增加而上升。与糖尿病发生相关的因素包括基线空腹血糖（FPG）水平、超重和肥胖状况。与FPG<93mg/dl者相比，FPG为93 - 99mg/dl和100 - 125mg/dl的校正发病率比（IRR，95%CI）分别为3.2[1.1 - 9.9]和31.5[11.4 - 86.8]。与BMI<23kg/m²者相比，BMI为23 - 27.5和>27.5kg/m²者的IRR分别为1.5[0.9 - 2.5]和2.7[1.6 - 4.5]。
本研究结果可作为泰国其他成年人群中估计2型糖尿病风险和程度的首个标记点。
