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嚼口香糖能否减少左侧结肠癌和直肠癌开放结肠切除术后的肠梗阻?一项前瞻性随机对照试验。

Does gum chewing reduce postoperative ileus following open colectomy for left-sided colon and rectal cancer? A prospective randomized controlled trial.

作者信息

Quah H M, Samad A, Neathey A J, Hay D J, Maw A

机构信息

Department of Colorectal and General Surgery, Glan Clwyd Hospital, Rhyl, UK.

出版信息

Colorectal Dis. 2006 Jan;8(1):64-70. doi: 10.1111/j.1463-1318.2005.00884.x.

Abstract

OBJECTIVE

Postoperative ileus is common after colorectal resection and can prolong hospital stay. Gum chewing, a type of sham feeding, may to stimulate gut motility via cephalic-vagal stimulation, and thereby reduce the length of ileus. This study aimed to determine whether gum chewing in the immediate postoperative period facilitated recovery from ileus following resection for left-sided colorectal cancer.

METHODS

In a prospective randomized control trial, 38 patients undergoing open surgery for left-sided colorectal cancer were allocated to standard postoperative care (control group, n = 19) or to standard postoperative care plus the immediate use of chewing gum (treatment group, n = 19).

RESULT

Control patients passed flatus by mean of 2.7 days (SD 1.0) and faeces by 3.9 days (SD 1.5); for the treatment group, this was 2.4 days (SD 1.0) and 3.2 days (SD 1.5) respectively, (NS, P = 0.56 and P = 0.38). Length of hospital stay was 11.1 days (SD 7.3) in control group and 9.4 days (SD 2.5) in the treatment group (NS, P = 0.75).

CONCLUSION

The addition of gum chewing to a standardized postoperative regimen did not reduce the period of postoperative ileus or shorten length of stay following open surgery for left-sided colorectal cancer.

摘要

目的

结直肠切除术后肠梗阻很常见,会延长住院时间。咀嚼口香糖是一种假饲方式,可能通过头迷走神经刺激来促进肠道蠕动,从而缩短肠梗阻时间。本研究旨在确定术后即刻咀嚼口香糖是否有助于左侧结直肠癌切除术后肠梗阻的恢复。

方法

在一项前瞻性随机对照试验中,38例接受左侧结直肠癌开放手术的患者被分配至标准术后护理组(对照组,n = 19)或标准术后护理加即刻使用口香糖组(治疗组,n = 19)。

结果

对照组患者平均在2.7天(标准差1.0)排气,3.9天(标准差1.5)排便;治疗组分别为2.4天(标准差1.0)和3.2天(标准差1.5),(无统计学差异,P = 0.56和P = 0.38)。对照组住院时间为11.1天(标准差7.3),治疗组为9.4天(标准差2.5)(无统计学差异,P = 0.75)。

结论

在标准化术后方案中增加咀嚼口香糖并不能减少左侧结直肠癌开放手术后的肠梗阻时间或缩短住院时间。

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