Kolar Lucija, Flajs Vesna Cerkvenik, Kuzner Jernej, Marc Irena, Pogacnik Milan, Bidovec Andrej, van Gestel Cornelis A M, Erzen Nevenka Kozuh
Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, SI-1000 Ljubljana, Slovenia.
Environ Pollut. 2006 Nov;144(1):197-202. doi: 10.1016/j.envpol.2005.12.019. Epub 2006 Mar 6.
We studied abamectin and doramectin excretion and their degradation in sheep faeces under field conditions on pasture after a single subcutaneous dose (0.2mg/kg body weight). In the excretion experiment, maximal abamectin concentration (1277 ng/g dry faeces) was detected on day 3, while doramectin concentration showed two peaks (2186 and 1780 ng/g dry faeces on days 2 and 5, respectively). Both avermectins were excreted at approximately the same rate (k=0.23 day(-1) for abamectin and 0.19 day(-1) for doramectin). In the field, a rapid loss of abamectin and doramectin from sheep faeces was seen during the first 32 days after which concentrations remained constant at approximately 77 ng/g and 300 ng/g, respectively. The half life values (DT(50)) for abamectin and doramectin dissipation from sheep faeces were 23 and 22 days, respectively, during the first 32 days. Dissipation of both avermectins was strongly correlated with moisture content of the faeces.
我们研究了在牧场野外条件下，给绵羊单次皮下注射剂量（0.2mg/kg体重）后，阿维菌素和多拉菌素在绵羊粪便中的排泄情况及其降解过程。在排泄实验中，第3天检测到阿维菌素的最大浓度（1277 ng/g干粪便），而多拉菌素浓度出现两个峰值（分别在第2天和第5天，为2186和1780 ng/g干粪便）。两种阿维菌素的排泄速率大致相同（阿维菌素的k = 0.23天⁻¹，多拉菌素的k = 0.19天⁻¹）。在野外，绵羊粪便中的阿维菌素和多拉菌素在最初32天内迅速减少，此后浓度分别保持在约77 ng/g和300 ng/g不变。在最初32天内，阿维菌素和多拉菌素从绵羊粪便中消散的半衰期值（DT₅₀）分别为23天和22天。两种阿维菌素的消散与粪便的水分含量密切相关。
