Bernasconi S, Torresani T, Illig R
J Clin Endocrinol Metab. 1975 May;40(5):759-63. doi: 10.1210/jcem-40-5-759.
The effect of synthetic alpha-MSH injected intravenously in a uniform dose of 3 mg was studied in 19 prepubertal children. A marked growth hormone (GH) response was seen only in 2 out of 8 constitutionally small children with a normal GH response to insulin and arginine stimulation. Three of of 11 children suffering from hypopituitarism with documented GH and other hormone deficiencies, unexpectedly, showed a significant rise of GH after alpha-MSH: all three had craniopharyngiomas. Alpha-MSH led to an increase of plasma cortisol in all except 3 patients who had secondary adrenal insuffciency. The increase of cortisol after alpha-MSH and after insulin was of the same extent: but the hypoglycemia and stress responsible for the insulin effect were not observed after alpha-MSH. It is possible that alpha-MSH acts by an ACTH-like direct stimulation on the adrenals. There was no effect of alpha-MSH on plasma TSH or on blood glucose.
对19名青春期前儿童静脉注射3毫克统一剂量的合成α-促黑素（α-MSH）的效果进行了研究。在8名体质瘦小但对胰岛素和精氨酸刺激有正常生长激素（GH）反应的儿童中，只有2名出现了明显的GH反应。在11名患有垂体功能减退且有记录的GH和其他激素缺乏的儿童中，出乎意料的是，3名儿童在注射α-MSH后GH显著升高：这3名儿童均患有颅咽管瘤。除3名继发性肾上腺功能不全的患者外，α-MSH使所有患者的血浆皮质醇增加。α-MSH和胰岛素注射后皮质醇的增加程度相同：但注射α-MSH后未观察到导致胰岛素效应的低血糖和应激反应。α-MSH可能通过类似促肾上腺皮质激素（ACTH）的方式直接刺激肾上腺。α-MSH对血浆促甲状腺激素（TSH）或血糖没有影响。
