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源自血红蛋白的血啡肽对血管紧张素转换酶活性具有抑制作用。

Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity.

作者信息

Lantz I, Glämsta E L, Talbäck L, Nyberg F

机构信息

Uppsala University, Department of Pharmacology, Sweden.

出版信息

FEBS Lett. 1991 Aug 5;287(1-2):39-41. doi: 10.1016/0014-5793(91)80011-q.

DOI:10.1016/0014-5793(91)80011-q
PMID:1652464
Abstract

The hemorphins are opioid active peptides, which are enzymatically released from the beta-chain of hemoglobin. In this paper we report an inhibitory effect of these peptides on angiotensin converting enzyme (ACE) activity, known to be involved in blood pressure regulation. The hemorphins were found to be quite stable in tissue extracts containing ACE, and their importance as naturally occurring ACE inhibitors is discussed.

摘要

血啡肽是阿片样活性肽，由血红蛋白的β链经酶解释放而来。在本文中，我们报道了这些肽对已知参与血压调节的血管紧张素转换酶（ACE）活性具有抑制作用。研究发现血啡肽在含有ACE的组织提取物中相当稳定，并对其作为天然存在的ACE抑制剂的重要性进行了讨论。

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