Slovin Susan F
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Nat Clin Pract Urol. 2006 Mar;3(3):138-44. doi: 10.1038/ncpuro0435.
Neuroendocrine differentiation of the prostate is often associated with a dismal prognosis. Whilst it is relatively rare compared with other forms of prostate cancer, it nevertheless remains difficult to treat these cancers effectively and to maintain a durable response. Research aimed at understanding the complexity of neuroendocrine differentiation of the prostate has been conducted for some time. The cells involved in this process secrete a variety of factors that can influence growth patterns and regulatory pathways. Many of these factors can be monitored serologically, but the relationship between the biology of the tumor and clinical response is often discordant. This review outlines the difficulties in treating this disease, both at the time of diagnosis and in the metastatic setting, and focuses on an area of research that remains challenging to both the researcher and clinician.
前列腺的神经内分泌分化通常与预后不良相关。虽然与其他形式的前列腺癌相比相对罕见，但有效治疗这些癌症并维持持久反应仍然困难。旨在了解前列腺神经内分泌分化复杂性的研究已经进行了一段时间。参与这一过程的细胞分泌多种可影响生长模式和调节途径的因子。其中许多因子可以通过血清学监测，但肿瘤生物学与临床反应之间的关系往往不一致。本综述概述了在诊断时和转移情况下治疗这种疾病的困难，并聚焦于一个对研究人员和临床医生来说都仍然具有挑战性的研究领域。
