一种构建新型3-H-苯并[d]吡唑并[1,5-b]异噻唑环系的一锅法合成途径。

A one-pot entry to a novel 3-H-benzo[d]pyrazolo[1,5-b]isothiazole ring system.

作者信息

Vicini Paola, Incerti Matteo, Ferretti Rocco, Zanardi Franca

机构信息

Dipartimento Farmaceutico, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43100, Parma, Italy.

出版信息

Mol Divers. 2006 May;10(2):251-3. doi: 10.1007/s11030-005-9011-3. Epub 2006 Mar 10.

DOI:10.1007/s11030-005-9011-3

PMID:16528601

Abstract

The phosphorus ylide obtained from the reaction between 2-aminobenzo[d]isothiazol-3-one and dimethyl acetylenedicarboxylate in the presence of triphenylphosphine undergoes a smooth intramolecular Wittig-type reaction to produce, in a one-pot reaction, 3-H-benzo[d]pyrazolo[1,5-b]isothiazole-2,3a-dicarboxylic acid dimethyl ester, a novel functionalized heterocyclic compound.

摘要

在三苯基膦存在下，由2-氨基苯并[d]异噻唑-3-酮与二甲基乙炔二羧酸酯反应得到的磷叶立德发生顺利的分子内维蒂希型反应，通过一锅法反应生成一种新型功能化杂环化合物——3-H-苯并[d]吡唑并[1,5-b]异噻唑-2,3a-二羧酸二甲酯。