Yavari Issa, Zabarjad-Shiraz Nader
Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran.
Mol Divers. 2006 Feb;10(1):23-7. doi: 10.1007/s11030-006-8696-2.
The stabilized phosphoranes, obtained from the three-component reaction between dialkyl acetylenedicarboxylates and urea or N-methylurea in the presence of triphenylphosphine, undergo a smooth reaction in boiling toluene to produce iminophosphoranes in good yields. Under the same reaction conditions, the phosphorane obtained from N-methylurea and dimethyl acetylenedicarboxylate yields methyl 1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylate.
在三苯基膦存在下，由二烷基乙炔二羧酸酯与尿素或N-甲基尿素发生三组分反应得到的稳定膦叶立德，在沸腾的甲苯中能顺利反应，以良好的产率生成亚氨基膦叶立德。在相同反应条件下，由N-甲基尿素和二甲基乙炔二羧酸酯得到的膦叶立德生成1-甲基-2,6-二氧代-1,2,3,6-四氢嘧啶-4-羧酸甲酯。
