Louail B, Sapoval M, Bonneau M, Wasseff M, Senechal Q, Gaux J-C
Department of Cardiovascular Radiology, Hôpital Européen Georges Pompidou, 20 Rue Leblanc, Paris 75015, France.
Cardiovasc Intervent Radiol. 2006 Sep-Oct;29(5):826-31. doi: 10.1007/s00270-004-0299-7.
To evaluate the safety and efficacy of a porcine-derived gelfoam, Curaspon, for the temporary occlusion of the visceral arteries.
Curaspon was used for the selective embolization of segmentary hepatic, unilateral polar renal, and single lumbar arteries of 10 pigs under general anesthesia. Sequential angiographic checks were carried out and the pigs killed between 3 days and 2 weeks later. Macroscopic and microscopic studies using standard techniques were used to evaluate the immediate efficacy of embolization, duration of and completeness of recanalization on angiography, macroscopic appearance of target-organ ischemia, and microscopic analysis of inflammatory reaction.
Immediate arterial occlusion was obtained in all cases. Renal arteries showed a total recanalization in 63% of cases on day 7 and 100% on day 14. Total hepatic recanalization was obtained in 100% of animals on day 7. All lumbar arteries were recanalized on day 14. Microscopic analysis in the kidney revealed a mild inflammatory reaction and a progressive lysis of the Curaspon (87% of samples at day 3 showed a persistence of Curaspon and 5% at day 14). In some cases, localized and partial destruction of the arterial wall was visualized. In the liver the same patterns were observed but resolved more completely and more rapidly.
Curaspon is an efficient material for the temporary occlusion of visceral and parietal arteries in pigs. However, arterial aneurysms were observed and a relationship of these with the material cannot be excluded.
评估一种猪源明胶海绵Curaspon用于暂时闭塞内脏动脉的安全性和有效性。
在全身麻醉下，使用Curaspon对10头猪的节段性肝动脉、单侧肾极动脉和单支腰动脉进行选择性栓塞。进行连续血管造影检查，并在3天至2周后处死猪。采用标准技术进行宏观和微观研究，以评估栓塞的即时效果、血管造影再通的持续时间和完整性、靶器官缺血的宏观表现以及炎症反应的微观分析。
所有病例均实现了即时动脉闭塞。肾动脉在第7天63%的病例中出现完全再通，第14天100%完全再通。肝动脉在第7天100%的动物中实现完全再通。所有腰动脉在第14天实现再通。肾脏的微观分析显示有轻度炎症反应，Curaspon逐渐溶解（第3天87%的样本显示Curaspon持续存在，第14天为5%）。在某些情况下，可见动脉壁的局部和部分破坏。在肝脏中观察到相同的模式，但消退更完全、更迅速。
Curaspon是一种用于暂时闭塞猪内脏和壁层动脉的有效材料。然而，观察到了动脉动脉瘤，且不能排除这些动脉瘤与该材料之间的关系。
