Department of Radiology, Johanniter-Hospital Bonn, Bonn, Germany.
Department of Radiology, University Hospital Bonn, Bonn, Germany.
Sci Rep. 2021 Dec 30;11(1):24506. doi: 10.1038/s41598-021-04155-1.
To evaluate the safety and impact of biopsy tract plugging with gelatin sponge slurry in percutaneous liver biopsy. 300 consecutive patients (158 females, 142 males; median age, 63 years) who underwent computed tomography-guided core biopsy of the liver in coaxial technique (16/18 Gauge) with and without biopsy tract plugging were retrospectively reviewed (January 2013 to May 2018). Complications were rated according to the common criteria for adverse events (NCI-CTCAE). The study cohort was dichotomized into a plugged (71%; n = 214) and an unplugged (29%; n = 86) biopsy tract group. Biopsy tract plugging with gelatin sponge slurry was technically successful in all cases. Major bleeding events were only observed in the unplugged group (0.7%; n = 2), whereas minor bleedings (4.3%) were observed in both groups (plugged, 3.6%, n = 11; unplugged, 0.7%, n = 2). Analysis of biopsies and adverse events showed a significant association between number of needle-passes and overall (P = 0.038; odds ratio: 1.395) as well as minor bleeding events (P = 0.020; odds ratio: 1.501). No complications associated with gelatin sponge slurry were observed. Biopsy tract plugging with gelatin sponge slurry is a technically easy and safe procedure that can prevent major bleeding events following liver biopsy.
评估经皮肝活检中使用明胶海绵浆进行活检道填塞的安全性和影响。回顾性分析了 2013 年 1 月至 2018 年 5 月期间，300 例连续接受同轴技术（16/18 号针）经 CT 引导下肝芯活检的患者（158 例女性，142 例男性；中位年龄 63 岁），其中 71%（n=214）的患者进行了活检道填塞，29%（n=86）的患者未进行活检道填塞。根据不良事件的常见标准（NCI-CTCAE）对并发症进行评分。研究队列分为填塞（71%；n=214）和未填塞（29%；n=86）活检道组。明胶海绵浆的活检道填塞在所有病例中均成功实施。仅在未填塞组观察到主要出血事件（0.7%；n=2），而两组均观察到轻微出血（4.3%）（填塞组 3.6%，n=11；未填塞组 0.7%，n=2）。活检和不良事件分析显示，针道数量与总体（P=0.038；优势比：1.395）以及轻微出血事件（P=0.020；优势比：1.501）之间存在显著相关性。未观察到与明胶海绵浆相关的并发症。明胶海绵浆进行活检道填塞是一种技术上简单且安全的方法，可预防肝活检后发生主要出血事件。
