Lauderdale Tsai-Ling, Aarestrup Frank M, Chen Pei-Chen, Lai Jui-Fen, Wang Hui-Ying, Shiau Yih-Ru, Huang I-Wen, Hung Che-Lun
Division of Clinical Research, National Health Research Institutes, Zhunan 350, Taiwan.
Diagn Microbiol Infect Dis. 2006 Jun;55(2):149-55. doi: 10.1016/j.diagmicrobio.2006.01.002. Epub 2006 Mar 9.
Of the 798 clinical Salmonella isolates collected from multiple hospitals in Taiwan, resistance to ampicillin (48.5%), chloramphenicol (55.3%), streptomycin (59.0%), sulfamethoxazole (68.0%), and tetracycline (67.8%) was high, whereas resistance to all 5 antimicrobials (ACSSuT R-type) comprised 327 (41%) and was highly prevalent in Salmonella enterica serotype Typhimurium (72.7%, 176/242), the most common serotype. Additional resistance to trimethoprim was present in 155 (19.4% overall) of the ACSSuT R-type isolates from several serotypes. Reduced susceptibility to fluoroquinolone (FQ) (ciprofloxacin MIC >0.125-1 microg/mL and nalidixic acid-resistant) was detected in 223 (27.9%) isolates including 117 (14.7% overall) that were also ACSSuT-resistant. Full resistance to FQ was detected in Salmonella Choleraesuis (35.5%, 6/17) and Salmonella Schwarzengrund (16.7%, 10/60); both serotypes were also multiresistant to other antimicrobials. Studies are needed to determine the sources of different multidrug-resistant serotypes. Continued national surveillance is underway to monitor changes in resistance trends and to detect further emergence of resistant Salmonella serotypes in Taiwan.
在从台湾多家医院收集的798株临床沙门氏菌分离株中，对氨苄西林（48.5%）、氯霉素（55.3%）、链霉素（59.0%）、磺胺甲恶唑（68.0%）和四环素（67.8%）的耐药率很高，而对所有5种抗菌药物（ACSSuT R型）的耐药率为327株（41%），在最常见的血清型肠炎沙门氏菌鼠伤寒血清型中高度流行（72.7%，176/242）。几种血清型的ACSSuT R型分离株中有155株（总体为19.4%）对甲氧苄啶有额外耐药性。在223株（27.9%）分离株中检测到对氟喹诺酮（FQ）（环丙沙星MIC>0.125-1微克/毫升且耐萘啶酸）敏感性降低，其中包括117株（总体为14.7%）也对ACSSuT耐药的菌株。在猪霍乱沙门氏菌（35.5%，6/17）和施瓦岑格鲁德沙门氏菌（16.7%，10/60）中检测到对FQ的完全耐药；这两种血清型对其他抗菌药物也多药耐药。需要开展研究以确定不同多药耐药血清型的来源。台湾正在持续进行全国监测，以监测耐药趋势的变化并检测耐药沙门氏菌血清型的进一步出现。
