Liao Ying-Shu, Lauderdale Tsai-Ling, Chang Jui-Hsien, Liang Shiu-Yun, Tsao Chi-Sen, Wei Hsiao Lun, Wang You-Wun, Teng Ru-Hsiou, Hong Yu-Ping, Chen Bo-Han, Chiou Chien-Shun
Center for Diagnostics and Vaccine Development, Centres for Disease Control, Taichung, Taiwan.
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
IJID Reg. 2024 May 1;11:100372. doi: 10.1016/j.ijregi.2024.100372. eCollection 2024 Jun.
, a zoonotic pathogen, significantly impacts global human health. Understanding its serotype distribution and antimicrobial resistance is crucial for effective control measures and medical interventions.
We collected isolates and demographic data from Taiwanese hospitals between 2004 and 2022, analyzing their serotypes and antimicrobial susceptibility.
Among 40,595 isolates, salmonellosis predominated in children aged 0-4 (61.2%) years and among males (55.2%). Males also showed higher rates of extraintestinal infections (18.1% vs 16.0%, <0.001), particularly, in the ≥65 years age group (52.4%). The top five serovars were Enteritidis (32.8%), Typhimurium (21.7%), Newport (6.2%), Stanley (4.7%), and Anatum (4.0%). Notably, . Enteritidis prevalence increased from 23.9% (2004-2005) to 43.6% (2021-2022). Antimicrobial resistance was high, with a 51.6% multidrug resistance (MDR) rate. Disturbingly, MDR rates exceeded 90% in serovars Albany, Schwarzengrund, Choleraesuis, and Goldcoast. Resistance to key therapeutic agents, azithromycin, cefotaxime, and ciprofloxacin, exhibited concerning upward trends, and the surge in cefotaxime and ciprofloxacin resistance was closely linked to the emergence and spread of MDR Anatum and Goldcoast clones.
Prioritizing control measures against . Enteritidis and closely monitoring the prevalence and spread of MDR clones are imperative to mitigate infections in Taiwan.
作为一种人畜共患病原体，对全球人类健康有重大影响。了解其血清型分布和抗菌药物耐药性对于采取有效的控制措施和医疗干预至关重要。
我们收集了2004年至2022年台湾医院的分离株和人口统计学数据，分析其血清型和抗菌药物敏感性。
在40595株分离株中，沙门氏菌病在0至4岁儿童中占主导地位（61.2%），在男性中也占主导地位（55.2%）。男性的肠外感染率也更高（18.1%对16.0%，P<0.001），特别是在≥65岁年龄组（52.4%）。前五种血清型为肠炎沙门氏菌（32.8%）、鼠伤寒沙门氏菌（21.7%）、纽波特沙门氏菌（6.2%）、斯坦利沙门氏菌（4.7%）和阿纳托姆沙门氏菌（4.0%）。值得注意的是，肠炎沙门氏菌的流行率从2004 - 2005年的23.9%上升到2021 - 2022年的43.6%。抗菌药物耐药性很高，多重耐药（MDR）率为5l.6%。令人不安的是，奥尔巴尼、施瓦曾格鲁德、猪霍乱和黄金海岸血清型的MDR率超过90%。对关键治疗药物阿奇霉素、头孢噻肟和环丙沙星的耐药性呈现出令人担忧的上升趋势，头孢噻肟和环丙沙星耐药性的激增与多重耐药阿纳托姆和黄金海岸克隆株的出现和传播密切相关。
优先采取针对肠炎沙门氏菌的控制措施并密切监测多重耐药克隆株的流行和传播对于减轻台湾地区的感染至关重要。
