Roeling T A, van Erp A M, Meelis W, Kruk M R, Veening J G
Department of Anatomy and Embryology, University of Nijmegen, The Netherlands.
Brain Res. 1991 Jun 7;550(2):220-4. doi: 10.1016/0006-8993(91)91321-q.
Electrical stimulation of the hypothalamic paraventricular nucleus (PVH) and of the adjacent dorsal hypothalamic area (DHA) evokes grooming behaviour. Microinjections of low doses of kainic acid, an agonist of the kainate type of glutamate receptors, into the same area evokes the same behaviour. To test whether other glutamate receptors are involved, microinjections with N-methyl-D-aspartic acid (NMDA) were made into the PVH/DHA area and the behaviour was observed. From the total observation time (30 min) up to 73% was spent on grooming, accompanied by yawning. Pronounced feeding behaviour was also noticed at 3 injection sites but not until 23 min after injection. Conclusions are that neurones within the PVH/DHA area are involved in grooming behaviour, possibly via glutamatergic innervation. The interaction between grooming and feeding behaviour at the level of the PVH is discussed.
对下丘脑室旁核（PVH）及相邻的下丘脑背侧区（DHA）进行电刺激可引发梳理行为。向同一区域微量注射低剂量的 kainic 酸（一种谷氨酸受体 kainate 型的激动剂）也会引发相同行为。为了测试是否有其他谷氨酸受体参与其中，将 N-甲基-D-天冬氨酸（NMDA）微量注射到 PVH/DHA 区域并观察行为。在总的观察时间（30 分钟）内，高达 73%的时间用于梳理，并伴有打哈欠。在 3 个注射部位还观察到明显的进食行为，但直到注射后 23 分钟才出现。结论是 PVH/DHA 区域内的神经元可能通过谷氨酸能神经支配参与梳理行为。本文还讨论了在 PVH 水平上梳理行为与进食行为之间的相互作用。
