van Erp A M, Kruk M R, Veening J G, Roeling T A, Meelis W
University of Leiden, The Netherlands.
Physiol Behav. 1995 May;57(5):881-5. doi: 10.1016/0031-9384(94)00334-2.
Electrical stimulation of the paraventricular (PVH) and adjacent hypothalamic area evokes self-grooming behaviour. Current intensity thresholds for grooming can be obtained depending on the exact localization of the electrode site. Sites localized at greater distance of the center of the grooming area evoke grooming at greater latencies and higher current intensity, or no grooming at all. Results are compared with injections of neuroactive substances into the PVH from previous studies, which showed a similar site specificity for grooming. We found similarity in the distribution of electrode sites in the paraventricular and anterior hypothalamic areas at which grooming is induced, and hypothalamic immunoreactive oxytocinergic neurons and fibres. In addition, we reported earlier that oxytocin infusions into the PVH in resting animals induce grooming, in contrast to other grooming-related peptides, such as alpha-melanocyte-stimulating hormone. We hypothesize that electrical stimulation may induce grooming by activation of oxytocinergic systems originating from the PVH.
对室旁核（PVH）及相邻下丘脑区域进行电刺激可诱发自我梳理行为。根据电极位点的确切定位，可以获得诱发梳理行为的电流强度阈值。位于离梳理区域中心较远位置的位点，诱发梳理行为的潜伏期更长、电流强度更高，或者根本不诱发梳理行为。将这些结果与之前研究中向室旁核注射神经活性物质的结果进行比较，后者显示出类似的诱发梳理行为的位点特异性。我们发现，在诱发梳理行为的室旁核和下丘脑前部区域，电极位点的分布与下丘脑免疫反应性催产素能神经元和纤维存在相似性。此外，我们之前报道过，与其他与梳理行为相关的肽（如α-黑素细胞刺激素）不同，向静息动物的室旁核注入催产素会诱发梳理行为。我们推测，电刺激可能通过激活源自室旁核的催产素能系统来诱发梳理行为。
